Protein Alignment CYP3A7 and Cyp6a21

DIOPT Version :9

• Sequence 1: NP_000756.3
• Gene: CYP3A7 / 1551
• HGNCID: 2640
• Length: 503
• Species: Homo sapiens
• Sequence 2: NP_611003.2
• Gene: Cyp6a21 / 36665
• FlyBaseID: FBgn0033981
• Length: 504
• Species: Drosophila melanogaster
• Alignment Length: 530
• Identity: 168/530 - (31%)
• Similarity: 274/530 - (51%)
• Gaps: 70/530 - (13%)

Human     7 LAVETWLLLAVSLILLYLY----GTRTHGLFKKLGIPGPTPLPFLGN------ALSFRKGYWTFD 61
            ::|.|.||.|:..::.||.    .|..|  ::.||||...|...:|:      |.||.: .||
  Fly     1 MSVGTVLLTALLALVGYLLMKWRSTMRH--WQDLGIPCEEPHILMGSMKGVRTARSFNE-IWT-- 60

Human    62 MECYKKYR---KVWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKN------- 116
             ..|.|:|   ...|.|..::|.:.:.:..:.|.:|:|| ::.||:|      ||..|
  Fly    61 -SYYNKFRGSGPFAGFYWFRRPAVFVLETSLAKQILIKE-FNKFTDR------GFFHNPEDDPLS 117

Human   117 -AISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIA----QYGDVLVRNLRREAETGKPVT-LKHV 175
             .:.:.:.::|:.:|:.||.||||||:|.|.|.:.    ::.||..:|:.:     .||. ::.:
  Fly   118 GQLFLLDGQKWRTMRNKLSSTFTSGKMKYMFPTVVKVANEFTDVFGQNVAK-----SPVVEVREL 177

Human   176 FGAYSMDVITSTSFGVSIDSLNNPQDPFVENTKKLLRFNPLDPFVLS-IKVFPFLTPILEALNIT 239
            ...::.|||.:.:||:...||.:|...|.|..::.|....|.|..:. :..||.|...|. :.:|
  Fly   178 LARFTTDVIGTCAFGIECSSLKDPDAEFREMGRRSLTEQRLGPVGIGFVNSFPNLARRLH-MKMT 241

Human   240 VFPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMIDSQN-----SKDSETHKALSDLELMAQS 299
            ..|  :..|..:.|::....| ::....|.||:..:||.:|     |:..|:.. |:..|:.||:
  Fly   242 AEP--IERFFMRIVRETVAFR-EQNNIRRNDFMDQLIDLKNKPLMVSQSGESVN-LTIEEIAAQA 302

Human   300 IIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPN-KAPPTYDTVLQLEYLDMVVNET 363
            .:|..||:||:|:.:.|.:||||.:.|:|.:|:||...|:.. .....|:::..|.|||.||:||
  Fly   303 FVFFAAGFETSSTTMGFALYELAQNQDIQNRVRKECQEVIEKCNGELNYESMKDLVYLDQVVSET 367

Human   364 LRLFPVAMRLERVCKKDVEING---MFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSK---K 422
            |||:.|...|.|.|.:|.|:.|   ..|.||:.|:||...:|.|.|.:..|..|.|:.||.   |
  Fly   368 LRLYTVLPVLNRECLEDYEVPGHPKYVIKKGMPVLIPCGAMHRDEKLYANPNTFNPDNFSPERVK 432

Human   423 NKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPL---KLRFGGLLL 484
            .:|:::   :.|||.||||||||||..:..::.|..::::|.|..|::|.||:   |..|  |:.
  Fly   433 ERDSVE---WLPFGDGPRNCIGMRFGQMQARIGLALLIKDFKFSVCEKTTIPMTYNKEMF--LIA 492

Human   485 TEKPIVLKAE 494
            :...|.||||
  Fly   493 SNSGIYLKAE 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A7	NP_000756.3	p450	39..492	CDD:365848	152/490 (31%)
Cyp6a21	NP_611003.2	p450	35..499	CDD:278495	152/489 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.820