DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CYP3A7 and Cyp6a9

DIOPT Version :9

Sequence 1:	NP_000756.3	Gene:	CYP3A7 / 1551	HGNCID:	2640	Length:	503	Species:	Homo sapiens
Sequence 2:	NP_523748.2	Gene:	Cyp6a9 / 36663	FlyBaseID:	FBgn0013771	Length:	504	Species:	Drosophila melanogaster

Alignment Length:	516	Identity:	160/516 - (31%)
Similarity:	265/516 - (51%)	Gaps:	53/516 - (10%)

- Green bases have known domain annotations that are detailed below.

Human    13 LLLAVSLIL---LYLYGTRTHGLFKKLGIPGPTPLPFLGN--ALSFRKGYWTFDMECYKKYRKVW 72
            :|||:.::|   |.|...|....::.|.||...|...:|:  .:...:.:....|:.|.|:|...
  Fly     6 VLLAIVVVLVGYLLLKWRRALHYWQNLDIPCEEPHILMGSLTGVQTSRSFSAIWMDYYNKFRGTG 70

Human    73 ---GIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKNA--------ISIAEDEEW 126
               |.|..|:|.:.:.|..:.|.:|:|| ::.||:|      ||..|.        :.:.:.::|
  Fly    71 PFAGFYWFQRPGILVLDISLAKLILIKE-FNKFTDR------GFYHNTEDDPLSGQLFLLDGQKW 128

Human   127 KRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFGV 191
            |.:||.||.||||||:|.|.|.:.:.|...:....:..|....|.::.:...::.|||.:.:||:
  Fly   129 KSMRSKLSYTFTSGKMKYMFPTVVKVGHEFIEVFGQAMEKSPIVEVRDILARFTTDVIGTCAFGI 193

Human   192 SIDSLNNPQDPFVENTKKLL---RFNPLD-PFVLSIKVFPFLTPILEALNITVFPRKVISFLTKS 252
            ...||.:|:..|....::.:   |..|:. .|:.|.:      .:...|::.:...:...|..:.
  Fly   194 ECSSLKDPEAEFRVMGRRAIFEQRHGPIGIAFINSFQ------NLARRLHMKITLEEAEHFFLRI 252

Human   253 VKQIKEGRLKETQKHRVDFLQLMIDSQNS--KDSETHKA--LSDLELMAQSIIFIFAGYETTSSV 313
            |::....|.|...: |.||:..:||.:||  ..||:.::  |:..|:.||:.:|..||:||:|:.
  Fly   253 VRETVAFREKNNIR-RNDFMDQLIDLKNSPLTKSESGESVNLTIEEMAAQAFVFFGAGFETSSTT 316

Human   314 LSFIIYELATHPDVQQKVQKEIDTVLPN-KAPPTYDTVLQLEYLDMVVNETLRLFPVAMRLERVC 377
            :.|.:||||.|.|:|.:|:||...|:.. ....||:::..:.|||.|::|||||:.|...|.|.|
  Fly   317 MGFALYELAQHQDIQDRVRKECQEVIGKYNGEITYESMKDMVYLDQVISETLRLYTVLPVLNREC 381

Human   378 KKDVEING---MFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSK---KNKDNIDPYIYTPFG 436
            .:|.|:.|   ..|.||:.|:||...:|.|.|.:..|..|.|:.||.   |.:|:::   :.|||
  Fly   382 LEDYEVPGHPKYVIKKGMPVLIPCGAMHRDEKLYANPNTFNPDNFSPERVKERDSVE---WLPFG 443

Human   437 SGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPL---KLRFGGLLLTEKPIVLKAE 494
            .||||||||||..:..:..|..::..|.|..|::|.||:   |..|  |:.:|..|.||.|
  Fly   444 DGPRNCIGMRFGQMQARSGLALLINRFKFSVCEQTTIPIVYSKKTF--LISSETGIFLKVE 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A7	NP_000756.3	p450	39..492	CDD:365848	148/483 (31%)
Cyp6a9	NP_523748.2	p450	35..499	CDD:278495	148/482 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8447
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.820