DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CYP3A7 and Cyp6t3

DIOPT Version :9

Sequence 1:	NP_000756.3	Gene:	CYP3A7 / 1551	HGNCID:	2640	Length:	503	Species:	Homo sapiens
Sequence 2:	NP_610745.1	Gene:	Cyp6t3 / 36318	FlyBaseID:	FBgn0033697	Length:	501	Species:	Drosophila melanogaster

Alignment Length:	514	Identity:	141/514 - (27%)
Similarity:	245/514 - (47%)	Gaps:	58/514 - (11%)

- Green bases have known domain annotations that are detailed below.

Human    12 WLLLAVSLILLYLYGTRTHGLFKKLGIP-----GPTPLPFLGNALSFRKGYWTFDMECYKKYR-- 69
            |||| ::::.|..:....:..|:..|||     ..:|:..||..|..|..:.....:.|...|
  Fly     5 WLLL-LTIVTLNFWLRHKYDYFRSRGIPHLPPSSWSPMGNLGQLLFLRISFGDLFRQLYADPRNG 68

Human    70 --KVWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKNAIS--IAEDEEWKRIR 130
              |:.|.:..|.|.|.:.||::|:.||:|. ::.|.||......|....|::  :|:...||..|
  Fly    69 QAKIVGFFIFQTPALMVRDPELIRQVLIKN-FNNFLNRFESADAGDPMGALTLPLAKYHHWKESR 132

Human   131 SLLSPTFTSGKLK-----EMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFG 190
            ..:|..||||:::     :|:.:.:.....|.|.|....|...|  |..:...|:.||..:..:.
  Fly   133 QCMSQLFTSGRMRDVMYSQMLDVASDLEQYLNRKLGDRLERVLP--LGRMCQLYTTDVTGNLFYS 195

Human   191 VSIDSLNNPQDPFVENTKKLLRFNP---LDPFVLSIKVFPFLTPILEALNITVFPRKVISFLTKS 252
            :::..|...:...:..||:|...||   ||  .:|:...|..|.:|:       |:.......:.
  Fly   196 LNVGGLRRGRSELITKTKELFNTNPRKVLD--FMSVFFLPKWTGVLK-------PKVFTEDYARY 251

Human   253 VKQIKEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSIIFIFAGYETTSSVLSFI 317
            ::.:.:...:.|:...::.||....|::|.....|...    :.:|:.|.:.||:||:|:::.|.
  Fly   252 MRHLVDDHHEPTKGDLINQLQHFQLSRSSNHYSQHPDF----VASQAGIILLAGFETSSALMGFT 312

Human   318 IYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVE 382
            :||||..||:|::::.|:.....:.|..:|||::.|.||.||..|.|||:|.|..:.|.|.....
  Fly   313 LYELAKAPDIQERLRSELREAFISTATLSYDTLMTLPYLKMVCLEALRLYPAAAFVNRECTSSAS 377

Human   383 IN-------GMFIPKGVVVMIPSYV----LHHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFG 436
            ..       ...:|.|    :|:|:    ||.|.::|.||..|.||||..:...:|.|..|.|||
  Fly   378 EGFSLQPHVDFIVPPG----MPAYISILGLHRDERFWPEPCVFDPERFGPERSRHIHPMTYIPFG 438

Human   437 SGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRFGGLLLTEKPIVLKAES 495
            :||..|||.|..::.:||.:|.:|:.:..:.|:.|  ..::||     ..|..:|::|:
  Fly   439 AGPHGCIGSRLGVLQLKLGIVHILKQYWVETCERT--VSEIRF-----NPKSFMLESEN 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A7	NP_000756.3	p450	39..492	CDD:365848	131/482 (27%)
Cyp6t3	NP_610745.1	p450	34..486	CDD:299894	130/478 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920