DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CYP3A7 and Cyp6a13

DIOPT Version :9

Sequence 1:	NP_000756.3	Gene:	CYP3A7 / 1551	HGNCID:	2640	Length:	503	Species:	Homo sapiens
Sequence 2:	NP_610390.1	Gene:	Cyp6a13 / 35837	FlyBaseID:	FBgn0033304	Length:	493	Species:	Drosophila melanogaster

Alignment Length:	505	Identity:	163/505 - (32%)
Similarity:	274/505 - (54%)	Gaps:	40/505 - (7%)

- Green bases have known domain annotations that are detailed below.

Human    11 TWLLLAVSLILLYLYGTRTH-GLFKKLGIPGPTPLPFLGNALSF-RKGYWT-FDMECYKKYRKV- 71
            |.|:|..::.||.....|.| ..:.:.|:.|..|:.|.||.... |..:|| .::..|:|:|.|
  Fly     3 TLLVLVFTVGLLLYVKLRWHYSYWSRRGVAGERPVYFRGNMSGLGRDLHWTDINLRIYRKFRGVE 67

Human    72 --WGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKNA--------ISIAEDEEW 126
              .|.:......|.|.|.::|:.::::: :|.|.:|      |...|.        :...:..||
  Fly    68 RYCGYFTFMTKSLFIMDLELIRDIMIRD-FSSFADR------GLFHNVRDDPLTGNLLFLDGPEW 125

Human   127 KRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFGV 191
            :.:|..|:..|||||:|.|.|.:.:.|:.|.:..|  .:.|: :..|.:...::.|||.|.:||:
  Fly   126 RWLRQNLTQVFTSGKMKFMFPNMVEVGEKLTQACR--LQVGE-IEAKDLCARFTTDVIGSCAFGL 187

Human   192 SIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTP-ILEALNITVFPRKVISFLTKSVKQ 255
            ..:||.:|:..|....:.:.: .||...:  ::.|.|..| :...|...:|..:|..|...:|:|
  Fly   188 ECNSLQDPESQFRRMGRSVTQ-EPLHSVL--VQAFMFAQPELARKLRFRLFRPEVSEFFLDTVRQ 249

Human   256 IKEGRLKETQKHRVDFLQLMID--SQNSKDSETHKALSDLELMAQSIIFIFAGYETTSSVLSFII 318
            ..:.|.:| ..||.|.:||:::  .:..||     |||..::.||:::|..||::|:|:.:||.:
  Fly   250 TLDYRRRE-NIHRNDLIQLLMELGEEGVKD-----ALSFEQIAAQALVFFLAGFDTSSTTMSFCL 308

Human   319 YELATHPDVQQKVQKEIDTVLP-NKAPPTYDTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVE 382
            ||||.:||||::::.|:..||. |....|||:|.::.|||.||.||||.:|:...|.|...|:.:
  Fly   309 YELALNPDVQERLRVEVLAVLKRNNQKLTYDSVQEMPYLDQVVAETLRKYPILPHLLRRSTKEYQ 373

Human   383 I--NGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGM 445
            |  :.:.:..|..::||.:.:||||:.:.:||||.|.||..:......|:.|.|||.|||||||.
  Fly   374 IPNSNLILEPGSKIIIPVHSIHHDPELYPDPEKFDPSRFEPEEIKARHPFAYLPFGEGPRNCIGE 438

Human   446 RFALVNMKLALVRVLQNFSFKPCKETQIPLKLRFGGLLL-TEKPIVLKAE 494
            ||..:.:|:.||.:|::|.|...::||||||......|: |::.:.|:.|
  Fly   439 RFGKLQVKVGLVYLLRDFKFSRSEKTQIPLKFSSRNFLISTQEGVHLRME 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A7	NP_000756.3	p450	39..492	CDD:365848	153/472 (32%)
Cyp6a13	NP_610390.1	p450	33..476	CDD:278495	151/461 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8447
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.820