Protein Alignment CYP3A7 and Cyp6a14

DIOPT Version :9

• Sequence 1: NP_000756.3
• Gene: CYP3A7 / 1551
• HGNCID: 2640
• Length: 503
• Species: Homo sapiens
• Sequence 2: NP_001286199.1
• Gene: Cyp6a14 / 35835
• FlyBaseID: FBgn0033302
• Length: 509
• Species: Drosophila melanogaster
• Alignment Length: 519
• Identity: 180/519 - (34%)
• Similarity: 275/519 - (52%)
• Gaps: 50/519 - (9%)

Human    11 TWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNALSFRKGYWTFDM--ECYKKYR---K 70
            |..|:.|.|.|.|....:....:|:.|:|..||||.:||.....|.|...|:  ..|||::   .
  Fly     4 TIALVGVVLGLAYSLHIKIFSYWKRKGVPHETPLPIVGNMRGIVKKYHFRDINQRIYKKFKGQGP 68

Human    71 VWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPF-----GPVGFMKNAISIAEDEEWKRIR 130
            :.|:|...:....|||.|.||.|::|: :|.|.:|..|     .|   :...:...|.|||:.:|
  Fly    69 IAGMYMFFKRTALITDLDFIKQVMIKD-FSYFQDRGAFTNPRDDP---LTGHLFALEGEEWRAMR 129

Human   131 SLLSPTFTSGKLKEMVPIIA----QYGDVLVRNLRR-EAETGKPVTLKHVFGAYSMDVITSTSFG 190
            ..|:|.|||||:|:|..:|.    :.||.:.:.::. :.|.|. |.:|.:...::.|||.|.:||
  Fly   130 HKLTPVFTSGKIKQMSKVIVDVGLRLGDAMDKAVKEAKVEEGN-VEIKDLCARFTTDVIGSCAFG 193

Human   191 VSIDSLNNPQDPFVENTKKLL---RFNPLDPFVLSIKVFPFLTP-ILEALNITVFPRKVISFLTK 251
            :..:||.:|...|.:..:::.   |.:.|      ::.|.|... :...|.|.|.|..:..|...
  Fly   194 LECNSLQDPSAEFRQKGREIFTRRRHSTL------VQSFIFTNARLARKLRIKVLPDDLTQFFMS 252

Human   252 SVKQIKEGRLKETQKHRVDFLQLMIDSQNSKDSETHK---------ALSDLELMAQSIIFIFAGY 307
            :||...:.|||...| |.||::.||:.: ::|.|..|         .|:..::.||:.:|..||:
  Fly   253 TVKNTVDYRLKNGIK-RNDFIEQMIELR-AEDQEAAKKGQGIDLSHGLTLEQMAAQAFVFFVAGF 315

Human   308 ETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPN--KAPPTYDTVLQLEYLDMVVNETLRLFPVA 370
            ||:||.:|..:||||..||:||::::||::||.|  .....||.:.|:.|||.|::||||..|:.
  Fly   316 ETSSSTMSLCLYELALQPDIQQRLREEIESVLANVDGGELNYDVLAQMTYLDQVLSETLRKHPLL 380

Human   371 MRLERVCKKDVEI--NGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPYIYT 433
            ..|.|...||.:|  :.:.:.||::.:||.:.:||||:.:.|||||.|.||..:...|..|..|.
  Fly   381 PHLIRETTKDYQIPNSDIVLDKGILALIPVHNIHHDPEIYPEPEKFDPSRFDPEEVKNRHPMAYL 445

Human   434 PFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPL---KLRFGGLLLTEKPIVLKAE 494
            |||.|||||||:||..:..|:.||.:|:.|.|.....|.:||   |..|  ||.|...|.||.|
  Fly   446 PFGDGPRNCIGLRFGKIQAKIGLVSLLRRFKFSVSNRTDVPLIFSKKSF--LLTTNDGIYLKVE 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A7	NP_000756.3	p450	39..492	CDD:365848	169/487 (35%)
Cyp6a14	NP_001286199.1	p450	32..506	CDD:306555	170/488 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8447
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.820