Protein Alignment CYP3A7 and Cyp4e2

DIOPT Version :9

• Sequence 1: NP_000756.3
• Gene: CYP3A7 / 1551
• HGNCID: 2640
• Length: 503
• Species: Homo sapiens
• Sequence 2: NP_001286196.1
• Gene: Cyp4e2 / 35822
• FlyBaseID: FBgn0014469
• Length: 526
• Species: Drosophila melanogaster
• Alignment Length: 495
• Identity: 125/495 - (25%)
• Similarity: 229/495 - (46%)
• Gaps: 70/495 - (14%)

Human    12 WLLLAVSLIL---LYLYGTRTHGLFKKLGIPGPTPLPFLGNALSFRK----------GYWTFDME 63
            ::.||:.|:|   |.|...|...:..|..  ||..||.:|||....|          .:|
  Fly     6 YIFLALPLLLVAYLELSTFRRRRVLNKFN--GPRGLPLMGNAHQMGKNPSEILDTVFSWW----- 63

Human    64 CYKKYRK----VW-GIYDCQQPMLAITDPDMIKTVLVKECY----SVFTNRRPFGPVGFMKNAIS 119
              .:|.|    .| |.|.    .:.:|....::.:|..:..    .::....|:..:|.:.:..|
  Fly    64 --HQYGKDNFVFWIGTYS----NVLVTSSKYLEFILSSQTLITKSDIYQLTHPWLGLGLLTSTGS 122

Human   120 IAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVI 184
                 :|.:.|.:::|.|....|::...::.:.....:::|:..|........:......::|||
  Fly   123 -----KWHKHRKMITPAFHFNILQDFHEVMNENSTKFIKHLKTVAAGDNIFDFQEQAHYLTLDVI 182

Human   185 TSTSFGVSIDSLNNPQDPFVENTK------KLLRFNPLDPFVLSIKV---FPFLTPILEALNITV 240
            ..|:.||||:::.|.....|:..|      .:..|:||....|..::   :|..:..|:.|.  .
  Fly   183 CDTAMGVSINAMENRSSSIVQAFKDMCYNINMRAFHPLKRNELLYRLAPDYPAYSRTLKTLQ--D 245

Human   241 FPRKVISFLTKSVKQIKEGRLK-----ETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSI 300
            |..::|:   |.::..|.|.:.     |..:.::.||..::.|     :...:.|:..||..:..
  Fly   246 FTNEIIA---KRIEAHKSGAVSTNAGDEFTRKKMAFLDTLLSS-----TIDGRPLNSKELYEEVS 302

Human   301 IFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNK---APPTYDTVLQLEYLDMVVNE 362
            .|:|.|::||:|.:||.:|.|:.|.|.|:|:.||...|:.|.   ...|:..:.|::|||:.:.|
  Fly   303 TFMFEGHDTTTSGVSFAVYLLSRHQDEQRKLFKEQREVMGNSELGRDATFQEISQMKYLDLFIKE 367

Human   363 TLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNI 427
            ..|::|....:.|..:||..|:|..:|||..:.:...:|.::.|.:.:|.||.||||..:..
  Fly   368 AQRVYPSVPFIGRFTEKDYVIDGDLVPKGTTLNLGLVMLGYNEKVFKDPHKFRPERFELEKP--- 429

Human   428 DPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKP 467
            .|:.|.||.:|||||||.:|||:.:|..:.::::||...|
  Fly   430 GPFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLP 469

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A7	NP_000756.3	p450	39..492	CDD:365848	117/465 (25%)
Cyp4e2	NP_001286196.1	p450	35..469	CDD:278495	116/462 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810