Protein Alignment CYP3A7 and Cyp4ad1

DIOPT Version :9

• Sequence 1: NP_000756.3
• Gene: CYP3A7 / 1551
• HGNCID: 2640
• Length: 503
• Species: Homo sapiens
• Sequence 2: NP_610380.1
• Gene: Cyp4ad1 / 35821
• FlyBaseID: FBgn0033292
• Length: 516
• Species: Drosophila melanogaster
• Alignment Length: 524
• Identity: 120/524 - (22%)
• Similarity: 224/524 - (42%)
• Gaps: 75/524 - (14%)

Human    14 LLAVSLIL---LYLYGTRTHGLFKKLG-----IPGPTPLPFLGNALSFRKGYWTFDMECYKKYRK 70
            |:|:::||   |...|.|.......:.     ||||||.||:||...|......:..:..:..||
  Fly     3 LIAIAIILATILVFKGVRIFNYIDHMAGIMEMIPGPTPYPFVGNLFQFGLKPAEYPKKVLQYCRK 67

Human    71 VWGIYDCQ--------QPMLAITDPDMIKTV------LVKECYSVFTNRRPFGPVGFMKNAISIA 121
                ||.|        |..:.::||..|:.:      |.||  .:::..||     ::.:.:..:
  Fly    68 ----YDFQGFRSLVFLQYHMMLSDPAEIQNILSSSSLLYKE--HLYSFLRP-----WLGDGLLTS 121

Human   122 EDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITS 186
            ....|.:.:.|.:|.|....::..:.::.:.|...|:.|...::|.:....:.:....::|::..
  Fly   122 SGARWLKHQKLYAPAFERSAIEGYLRVVHRTGGQFVQKLDVLSDTQEVFDAQELVAKCTLDIVCE 186

Human   187 TSFGVSIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTPILEALNITVF---PRKVISF 248
            .:.|....|||..........|.|..       |:..:.|..:........:|.:   .|:.:|.
  Fly   187 NATGQDSSSLNGETSDLHGAIKDLCD-------VVQERTFSIVKRFDALFRLTSYYMKQRRALSL 244

Human   249 LTKSVKQI---------KEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSIIFIF 304
            |...:.:|         .|...::.|.....||.:::.::..     .|.|.:.|::.:...|||
  Fly   245 LRSELNRIISQRRHQLAAENTCQQGQPINKPFLDVLLTAKLD-----GKVLKEREIIEEVSTFIF 304

Human   305 AGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVL--QLEYLDMVVNETLRLF 367
            .|::..::.:||.:|.|:.|.::|||..:|...:.........|...  |:.||::::.|||||:
  Fly   305 TGHDPIAAAISFTLYTLSRHSEIQQKAAEEQRRIFGENFAGEADLARLDQMHYLELIIRETLRLY 369

Human   368 PVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKD-NIDPYI 431
            |....:.|..:..::|||..:.|...|::....:.::.||:.:|..|.||||.....: .|:.:.
  Fly   370 PSVPLIARTNRNPIDINGTKVAKCTTVIMCLIAMGYNEKYFDDPCTFRPERFENPTGNVGIEAFK 434

Human   432 YTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRFGGLLLTEKPIVLKAESR 496
            ..||.:|||.||..:||:..||..|.::|:.|...|..:          ||     |..:...||
  Fly   435 SVPFSAGPRRCIAEKFAMYQMKALLSQLLRRFEILPAVD----------GL-----PPGINDHSR 484

Human   497 DETV 500
            ::.|
  Fly   485 EDCV 488

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A7	NP_000756.3	p450	39..492	CDD:365848	109/481 (23%)
Cyp4ad1	NP_610380.1	p450	36..470	CDD:278495	105/456 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810