Protein Alignment CYP3A7 and Cyp9b1

DIOPT Version :9

• Sequence 1: NP_000756.3
• Gene: CYP3A7 / 1551
• HGNCID: 2640
• Length: 503
• Species: Homo sapiens
• Sequence 2: NP_523645.1
• Gene: Cyp9b1 / 35634
• FlyBaseID: FBgn0015038
• Length: 505
• Species: Drosophila melanogaster
• Alignment Length: 499
• Identity: 157/499 - (31%)
• Similarity: 268/499 - (53%)
• Gaps: 60/499 - (12%)

Human     9 VETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGN----AL---SFRKGYWTFDMECYK 66
            ||..|:||...:||:.:.|.|...|:...:....|.|||||    ||   ||:|..    .|.|.
  Fly     4 VEICLVLATIGLLLFKWSTGTFKAFEGRNLYFEKPYPFLGNMAASALQKASFQKQI----SEFYN 64

Human    67 KYR--KVWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVG--FMKNAISIAEDEEWK 127
            :.|  |:.|:::.:.||:.|.||.:||.:.||: :..|.|.:......  .:.:.:::..|:.|:
  Fly    65 RTRHHKLVGLFNLRTPMIQINDPQLIKKICVKD-FDHFPNHQTLNIPNERLVNDMLNVMRDQHWR 128

Human   128 RIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRRE-----AETGKPVTLKHVFGAYSMDVITST 187
            .:||:|:|.|||.|::.|..::.:.....:.:|:..     .|....:.:|.:....|.|||.:|
  Fly   129 NMRSVLTPVFTSAKMRNMFTLMNESFAQCLEHLKSSQPIAAGENAFELDMKVLCNKLSNDVIATT 193

Human   188 SFGVSIDSLNNPQDPFVENTKKLLRFNPLDPF------VLSIKVFPF--LTPILEALNITVFPRK 244
            :||:.::|.::|::.| ....|.|.|:...||      :|:.|||.|  || |.::.|:..|.|.
  Fly   194 AFGLKVNSFDDPENEF-HTIGKTLAFSRGLPFLKFMMCLLAPKVFNFFKLT-IFDSTNVEYFVRL 256

Human   245 VISFLTKSVKQIKEGRLKETQKH---RVDFLQLMIDS-QNSKDSETHKALSDLELMAQSIIFIFA 305
            |:..:     |.:|       ||   |.|.:||:::: :.|||:.|     |.|::||..||.||
  Fly   257 VVDAM-----QYRE-------KHNITRPDMIQLLMEAKKESKDNWT-----DDEIVAQCFIFFFA 304

Human   306 GYETTSSVLSFIIYELATHPDVQQKVQKEI-DTVLPNK-APPTYDTVLQLEYLDMVVNETLRLFP 368
            .:|..|:::....|||..:.|:|:::.:|: :|....| ||.|||...::.|:|||::|:||.:.
  Fly   305 AFENNSNLICTTAYELLRNLDIQERLYEEVKETQEALKGAPLTYDAAQEMTYMDMVISESLRKWT 369

Human   369 VAMRLERVCKKDVEING-----MF-IPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNI 427
            ::...:|:|.||..:..     :| ...|..:.||...||.|.:::.:|::|.|||||::.|.::
  Fly   370 LSAAADRLCAKDYTLTDDEGTKLFEFKAGDNINIPICGLHWDERFFPQPQRFDPERFSERRKKDL 434

Human   428 DPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKET 471
            .||.|.|||.|||:|||.|:|::..|..|..::.|:..:....|
  Fly   435 IPYTYLPFGVGPRSCIGNRYAVMQAKGMLYNLMLNYKIEASPRT 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A7	NP_000756.3	p450	39..492	CDD:365848	147/469 (31%)
Cyp9b1	NP_523645.1	p450	37..478	CDD:299894	146/464 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	262	1.000	Domainoid score	I1946
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	277	1.000	Inparanoid score	I2940
Isobase	1	0.950	-	0	Normalized mean entropy	S3417
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.820