Protein Alignment CYP3A7 and Cyp310a1

DIOPT Version :9

• Sequence 1: NP_000756.3
• Gene: CYP3A7 / 1551
• HGNCID: 2640
• Length: 503
• Species: Homo sapiens
• Sequence 2: NP_609891.1
• Gene: Cyp310a1 / 35115
• FlyBaseID: FBgn0032693
• Length: 492
• Species: Drosophila melanogaster
• Alignment Length: 508
• Identity: 123/508 - (24%)
• Similarity: 226/508 - (44%)
• Gaps: 116/508 - (22%)

Human    12 WLLL------AVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNALSFRKGY-WTFDMECYKK-- 67
            ||||      ||.|.:.::|   :|  :::.|.|            |.:.|. |:|..:.|::
  Fly     2 WLLLPILLYSAVFLSVRHIY---SH--WRRRGFP------------SEKAGITWSFLQKAYRREF 49

Human    68 ---------YR----KVWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMK-NAI 118
                     |:    ::.|||...:|:|.:.:.::.:|:|          ::..|....:| :.|
  Fly    50 RHVEAICEAYQSGKDRLLGIYCFFRPVLLVRNVELAQTIL----------QQSNGHFSELKWDYI 104

Human   119 SIAEDEEWKRIRSL--LSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKP--VTLKHVFGAY 179
            |     .::|...|  |:|.|.:.:|.||...:.:.||.|:.:|......|.|  |.::.....|
  Fly   105 S-----GYRRFNLLEKLAPMFGTKRLSEMFGQVQKVGDHLIHHLLDRQGQGCPQEVDIQQKLRVY 164

Human   180 SMDVITSTSFGVSIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLT---PILEALNITVF 241
            |:::|.:..:|:.|   ||              |...|..:.|     :|:   ..:::..:...
  Fly   165 SVNIIANLIYGLDI---NN--------------FEHEDHILTS-----YLSHSQASIQSFTLGRL 207

Human   242 PRKVISFLTKSVKQIKEGRLKETQKH---RVDFLQLMIDSQNSKD-----------SETHKALSD 292
            |:|  |..|..::.:.:..::..:.|   |.|.|||::..:|..:           ::..|.||.
  Fly   208 PQK--SSYTYRLRDLIKQSVELREDHGLIRKDILQLLVRFRNGNEVSGDKWQLEPINDADKLLSI 270

Human   293 LELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLD 357
            ..|...:...:....:..:|.::|.:.|:...|.:.:|::.||..:........::.:..|.|:|
  Fly   271 KRLAKVAEDLLKVSLDAVASTVTFTLLEILQEPLIVEKLRAEIKELSNENGQLKFEELNGLRYMD 335

Human   358 MVVNETLRLFPVAMRLERVCKKDVEI-NGMF-IPKGVVVMIPSYVLHHDPKYWTEPEKFLPERF- 419
            |.:.||||.:|....:||||:|...: |..| |.:|..:|:|...:|.|.||::||.|:.|.||
  Fly   336 MCLKETLRKYPPLPIIERVCRKSYSLPNSKFTIDEGKTLMVPLLAMHRDEKYFSEPMKYKPLRFL 400

Human   420 ---------SKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNF 463
                     ..|.|.|    ::..||.|...|:|..||.:.:|:||:::||||
  Fly   401 QTANDVGQCEDKTKSN----VFIGFGIGGSQCVGQNFAKLVIKVALIKLLQNF 449

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A7	NP_000756.3	p450	39..492	CDD:365848	113/475 (24%)
Cyp310a1	NP_609891.1	p450	69..454	CDD:299894	105/424 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920