DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CYP3A7 and Cyp28d1

DIOPT Version :9

Sequence 1:	NP_000756.3	Gene:	CYP3A7 / 1551	HGNCID:	2640	Length:	503	Species:	Homo sapiens
Sequence 2:	NP_608912.1	Gene:	Cyp28d1 / 33749	FlyBaseID:	FBgn0031689	Length:	502	Species:	Drosophila melanogaster

Alignment Length:	483	Identity:	138/483 - (28%)
Similarity:	242/483 - (50%)	Gaps:	40/483 - (8%)

- Green bases have known domain annotations that are detailed below.

Human    14 LLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGN--ALSFRKGYWTFDM-ECYKKYR---KVW 72
            ::|..|.|:|::.|.....:||.|||.....||:|:  ::..:|....:|: |.|::|:   .:.
  Fly    10 VIAAILALIYVFLTWNFSYWKKRGIPTAKSWPFVGSFPSVFTQKRNVVYDIDEIYEQYKNTDSIV 74

Human    73 GIYDCQQPMLAITDPDMIKTVLVKECYSV-------FTNRRPFGPVGFMKNAISIAEDEEWKRIR 130
            |::..:.|.|.:|.|:....:.|.:..|.       ||:.:. .|:  :.|...:...|.||..|
  Fly    75 GVFQTRIPQLMVTTPEYAHKIYVSDFRSFHDNEMAKFTDSKT-DPI--LANNPFVLTGEAWKERR 136

Human   131 SLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREA--ETGKPVTLKHVFGAYSMDVITSTSFGVSI 193
            :.::|..::.::|...|:..:.....|..:||::  ...:.:..|.:...|:.:||:....|:|.
  Fly   137 AEVTPGLSANRVKAAYPVSLRVCKKFVEYIRRQSLMAPAQGLNAKDLCLCYTTEVISDCVLGISA 201

Human   194 DSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTPILEALNITVFPRKVISFLTKSV-KQIK 257
            .|..:...|.|..||::  |.....|:....|.....||.:..::::|.:.|.:|....: |.|:
  Fly   202 QSFTDNPTPMVGMTKRV--FEQSFGFIFYTVVANLWPPITKFYSVSLFAKDVAAFFYDLMQKCIQ 264

Human   258 EGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELA 322
            ..|.....:.|.|||..|:..|..      |.|:..||.:.::.|:..|:|||:.||:..:..||
  Fly   265 VRRESPAAQQRDDFLNYMLQLQEK------KGLNAAELTSHTMTFLTDGFETTAQVLTHTLLFLA 323

Human   323 THPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVEI---N 384
            .:|..|.|:::||.|     |..|::.:.:|.:.:..::||||:|...:...:|..:..|:   |
  Fly   324 RNPKEQMKLREEIGT-----AELTFEQISELPFTEACIHETLRIFSPVLAARKVVTEPCELTNKN 383

Human   385 GMFIP--KGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKN---KDNIDPYIYTPFGSGPRNCIG 444
            |:.:.  .|.||:||...|||||:|:.||:.|.||||...|   |...|..::..||.|||.|.|
  Fly   384 GVSVKLRPGDVVIIPVNALHHDPQYYEEPQSFKPERFLNINGGAKKYRDQGLFFGFGDGPRICPG 448

Human   445 MRFALVNMKLALVRVLQNFSFKPCKETQ 472
            |||:|..:|.|||.:::||..|...:|:
  Fly   449 MRFSLTQIKAALVEIVRNFDIKVNPKTR 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A7	NP_000756.3	p450	39..492	CDD:365848	129/458 (28%)
Cyp28d1	NP_608912.1	p450	35..477	CDD:278495	129/458 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920