Protein Alignment CYP3A7 and Cyp309a2

DIOPT Version :9

• Sequence 1: NP_000756.3
• Gene: CYP3A7 / 1551
• HGNCID: 2640
• Length: 503
• Species: Homo sapiens
• Sequence 2: NP_608689.2
• Gene: Cyp309a2 / 33439
• FlyBaseID: FBgn0041337
• Length: 538
• Species: Drosophila melanogaster
• Alignment Length: 516
• Identity: 134/516 - (25%)
• Similarity: 240/516 - (46%)
• Gaps: 74/516 - (14%)

Human     1 MDLIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGN--ALSFRKGYWTFDME 63
            |.::.:||:   :||.:.::.:|||.|..|..::|.|:....||..||.  .|..||....||::
  Fly    32 MYILASLAL---ILLHLLVLPIYLYLTWHHKYWRKRGLVTARPLTLLGTYPGLLTRKSNLVFDVQ 93

Human    64 -CYKKYR---KVWGIYDCQQPMLAITDPDMIKTVLVK--ECY--------------SVFTNRRPF 108
             .|.||:   :..|::..:||.:.:.||::...|||.  .||              ..:....||
  Fly    94 KIYDKYKGKHRAVGVFVTRQPQILVLDPELAHEVLVSNFRCYKDSLQSSYLRHAKWDKYARLNPF 158

Human   109 GPVGFMKNAISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRRE-AETGKPVTL 172
            .           |..:.|:|:|:......:..:|::...|..|.|.:|...:.:: ||....:..
  Fly   159 W-----------ASGQSWRRLRTDAQAGISGSRLRQAYNIWEQGGQMLTEYMTQQVAEKNNILET 212

Human   173 KHVFGAYSMDVITSTSFGVSIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTPILE-AL 236
            :.:...|:..|:....:|:...:|..|.:...:..:...::.....::|::.:...:.|... .|
  Fly   213 RDLCFRYTAHVMADFIWGIDAGTLTRPMEQPNKVQEMASKWTSYAFYMLTLFMATIVAPCSRLLL 277

Human   237 NITVFPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSII 301
            ....:|::...|.:...|:..|.|||.....|.|:|..::..::.|.: ||.     :|:..::.
  Fly   278 RFRFYPKETDEFFSNLTKESIELRLKAGDSTRTDYLSHLLQLRDQKQA-THD-----DLVGHALT 336

Human   302 FIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVVNETLRL 366
            .:..||:|:.:.|...:|.||.:|.||||::.||.:.:.::....::.:..|:||:.|:.|:|||
  Fly   337 VMLDGYDTSGTALLHALYYLAENPAVQQKLRVEILSCMASEKSLDFEKLSSLQYLEQVIYESLRL 401

Human   367 ------------FPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERF 419
                        .|..:||......|||:       |:.:|||:|..|||.:|:.|||.|.||||
  Fly   402 SSLIPQYTKVCTLPTVIRLSESKSLDVEV-------GMTIMIPNYQFHHDKQYFPEPEAFKPERF 459

Human   420 SKKNKDN------IDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIP 474
                 ||      :...|:.||..|||.|:|:..|::.:|.|||.:|.||.....::..||
  Fly   460 -----DNGAYQELMRKGIFLPFSDGPRICMGVPLAMLTLKSALVHILSNFQVVRGRDRLIP 515

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A7	NP_000756.3	p450	39..492	CDD:365848	122/478 (26%)
Cyp309a2	NP_608689.2	p450	70..526	CDD:299894	122/475 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920