Protein Alignment CYP3A7 and Cyp4s3

DIOPT Version :9

• Sequence 1: NP_000756.3
• Gene: CYP3A7 / 1551
• HGNCID: 2640
• Length: 503
• Species: Homo sapiens
• Sequence 2: NP_573003.2
• Gene: Cyp4s3 / 32444
• FlyBaseID: FBgn0030615
• Length: 495
• Species: Drosophila melanogaster
• Alignment Length: 533
• Identity: 147/533 - (27%)
• Similarity: 248/533 - (46%)
• Gaps: 87/533 - (16%)

Human     7 LAVETWLLLAVSL-----ILLYLYGTRTHGLFKKLGIPGPTPLPFLGNALSFRKG---YWTFDME 63
            ||:..::|.|..|     ||.:|...|    |.|. :||||....:.|.   :||   .|.  .|
  Fly     4 LALVAFVLWAAFLRYLPKILNFLRLQR----FAKT-LPGPTIGELIANV---KKGEILNWL--KE 58

Human    64 CYKKYRKVWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRR------PFGPVGFMKNAISIAE 122
            ..:|:..|:.|:..:..|:..|||:.||.:|...  .:.|..|      |:...|.:.|.
  Fly    59 LREKHGPVFRIWFGKDLMVMFTDPEDIKQLLGNN--QLLTKSRNYELLEPWLGKGLLTNG----- 116

Human   123 DEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITST 187
            .|.|.|.|.||:|.|....|.|....:.:...:|||.||.:| .|:...:......:::|.|..|
  Fly   117 GESWHRRRKLLTPGFHFRILSEFKEPMEENCRILVRRLRTKA-NGESFDIYPYITLFALDAICET 180

Human   188 SFGVSIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTPILEALNITVFPR--------- 243
            :.|:...:.......:|:..:.:.|       |:..:.|.|    .:.||: .|..
  Fly   181 AMGIKKHAQLQSDSEYVQAVQSICR-------VMHKQSFSF----WQRLNV-FFKHTKPGKEREA 233

Human   244 --KVISFLTKSVKQIKEGRLKETQ--------------KHRVDFLQLMIDSQNSKDSETHKALSD 292
              ||:...|..|.:::..:|.:.:              |.|:.||.:::.:|....:|    |||
  Fly   234 ALKVLHDETNRVIRLRREQLIQERNEWKPEAEQDDVGAKRRLAFLDMLLLTQMEGGAE----LSD 294

Human   293 LELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLD 357
            .::..:...|:|.|::||||.::|.:..|:.:|||||:..:|...:...:..       .:.||:
  Fly   295 TDIREEVDTFMFEGHDTTSSAIAFALSLLSKNPDVQQRAFEEASELEGREKE-------SMPYLE 352

Human   358 MVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKK 422
            .|:.||||::|......|...:|:|:..:.:|||..:....|:||.|||.:.:||:|.|:|| ..
  Fly   353 AVIKETLRIYPSVPFFSRKVLEDLEVGKLTVPKGASISCLIYMLHRDPKNFPDPERFDPDRF-LV 416

Human   423 NKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRFGGLLLTE- 486
            |:..:.|:.:..|.:|||||||.:||::.:|.:|..:|:::.|.|.|:.| |..|   ..|:|:
  Fly   417 NEKQMHPFAFAAFSAGPRNCIGQKFAMLELKTSLAMLLRSYRFLPDKDHQ-PKPL---AELVTKS 477

Human   487 -KPIVLKAESRDE 498
             ..|.|:...|||
  Fly   478 GNGIRLRILPRDE 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A7	NP_000756.3	p450	39..492	CDD:365848	132/488 (27%)
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	128/471 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810