DRSC/TRiP Functional Genomics Resources

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Protein Alignment CYP3A7 and Cyp4d2

DIOPT Version :9

Sequence 1:NP_000756.3 Gene:CYP3A7 / 1551 HGNCID:2640 Length:503 Species:Homo sapiens
Sequence 2:NP_001284806.1 Gene:Cyp4d2 / 31192 FlyBaseID:FBgn0011576 Length:501 Species:Drosophila melanogaster


Alignment Length:491 Identity:149/491 - (30%)
Similarity:253/491 - (51%) Gaps:61/491 - (12%)


- Green bases have known domain annotations that are detailed below.


Human    13 LLLAVSLILL--YLYGTRTHGLFKKLGIPGPTPLPFLGNALSFR----KGYWTFDMECYKKYRKV 71
            ||:|.:.:||  :|:..|.:|:     :|||.|||||||.|.:|    :....|..:..:||.::
  Fly     9 LLVAFATLLLWDFLWRRRGNGI-----LPGPRPLPFLGNLLMYRGLDPEQIMDFVKKNQRKYGRL 68

Human    72 WGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVG-FMKNAISIAEDEEWKRIRSLLSP 135
            :.::...|..:..|||..|:.||..:.:  .|....:..:. ::.:.:.::...:|...|.:::|
  Fly    69 YRVWILHQLAVFSTDPRDIEFVLSSQQH--ITKNNLYKLLNCWLGDGLLMSTGRKWHGRRKIITP 131

Human   136 TFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFGVSIDSLNNPQ 200
            ||....|::.|.|..|...|:|..|:..|:...|:.:..|....::|:|..|:.|..|::..||.
  Fly   132 TFHFKILEQFVEIFDQQSAVMVEQLQSRADGMTPINIFPVICLTALDIIAETAMGTKINAQKNPN 196

Human   201 DPFVENTKKLLRFNPLDPFVLSIKVFPFLTP------ILEALNITVFPR-----KVISFLTKSVK 254
            .|:|:....          |.:|.:..|:..      |......|...|     ||:...|::: 
  Fly   197 LPYVQAVND----------VTNILIKRFIHAWQRVDWIFRLTQPTEAKRQDKAIKVMHDFTENI- 250

Human   255 QIKEGR------LKET----------QKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSIIFI 303
             |:|.|      .|||          ||.|:..|.:::  |::.|.   ..|||.::..:...|:
  Fly   251 -IRERRETLVNNSKETTPEEEVNFLGQKRRMALLDVLL--QSTIDG---APLSDEDIREEVDTFM 309

Human   304 FAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVL--PNKAPPTYDTVLQLEYLDMVVNETLRL 366
            |.|::||:|.:||.:||::.||:|||::|:||..||  ..|:|.|...:.:|::::.|:.|:|||
  Fly   310 FEGHDTTTSAISFCLYEISRHPEVQQRLQQEIRDVLGEDRKSPVTLRDLGELKFMENVIKESLRL 374

Human   367 FPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPYI 431
            .|....:.|...:||||.|..||.|....:..:||..||:|:..|::|.||||. .:...|.||.
  Fly   375 HPPVPMIGRWFAEDVEIRGKHIPAGTNFTMGIFVLLRDPEYFESPDEFRPERFD-ADVPQIHPYA 438

Human   432 YTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKP 467
            |.||.:|||||||.:||::.||..:.::|::|...|
  Fly   439 YIPFSAGPRNCIGQKFAMLEMKSTVSKLLRHFELLP 474

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CYP3A7NP_000756.3 p450 39..492 CDD:365848 141/463 (30%)
Cyp4d2NP_001284806.1 p450 32..495 CDD:278495 141/463 (30%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100014
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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