DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ADRB3 and Octbeta1R

DIOPT Version :9

Sequence 1:	NP_000016.1	Gene:	ADRB3 / 155	HGNCID:	288	Length:	408	Species:	Homo sapiens
Sequence 2:	NP_001262843.1	Gene:	Octbeta1R / 42652	FlyBaseID:	FBgn0038980	Length:	508	Species:	Drosophila melanogaster

Alignment Length:	342	Identity:	121/342 - (35%)
Similarity:	186/342 - (54%)	Gaps:	39/342 - (11%)

- Green bases have known domain annotations that are detailed below.

Human    43 LLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGA 107
            ::...:||.:.||:||||::....:|:.:||.||.|||.||:::.|..:...|::.::|.|..|:
  Fly   113 IIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGS 177

Human   108 TGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAP 172
            ..|::|.|.||...||||..||.::||||.|:..||.|..::|:|.....:::||:..|.:||.|
  Fly   178 VMCDMWNSFDVYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLP 242

Human   173 IMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRL 237
            |.|.|:....:.:..:  |||..|.|..|..|.::|||:||::|.:|||.:|.|::..|.||.||
  Fly   243 ICSGWYTTTENYKYLK--SNPHICEFKVNKAYAIVSSSMSFWIPGIVMLSMYYRIYQEADRQERL 305

Human   238 L-RGELGRFPPEE-------SPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTL 294
            : |.::.....|:       ..|.||..:..:.:.|..                  ||.:|..||
  Fly   306 VYRSKVAALLLEKHLQISQIPKPRPSIQVEQSTISTMR------------------RERKAARTL 352

Human   295 GLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCR-SPDFRSAFRR 358
            |:||..|.:|||||||..::.:|....:.|......|.|:||.|||.||:||.. :.|||:||::
  Fly   353 GIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAFKK 417

Human   359 LL----------CRCGR 365
            .|          ||.||
  Fly   418 TLKSLFPYAFYFCRRGR 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ADRB3	NP_000016.1	7tm_GPCRs	51..356	CDD:333717	112/313 (36%)
		TM helix 2	73..95	CDD:320095	9/21 (43%)
		TM helix 3	111..133	CDD:320095	10/21 (48%)
		TM helix 4	156..172	CDD:320095	5/15 (33%)
		TM helix 5	202..225	CDD:320095	10/22 (45%)
		TM helix 6	288..313	CDD:320095	14/24 (58%)
		TM helix 7	325..350	CDD:320095	11/25 (44%)
Octbeta1R	NP_001262843.1	7tm_4	112..>231	CDD:304433	44/117 (38%)
Octbeta1R	NP_001262843.1	7tm_1	124..404	CDD:278431	107/299 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40768
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24248
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X822
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	4.010