Protein Alignment ADRB3 and adrb2

DIOPT Version :10

• Sequence 1: NP_000016.1
• Gene: ADRB3 / 155
• HGNCID: 288
• Length: 408
• Species: Homo sapiens
• Sequence 2: NP_001116897.2
• Gene: adrb2 / 100144654
• XenbaseID: XB-GENE-494302
• Length: 419
• Species: Xenopus tropicalis
• Alignment Length: 407
• Identity: 179/407 - (43%)
• Similarity: 239/407 - (58%)
• Gaps: 44/407 - (10%)

Human     5 PHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQ 69
            |:.||:|   ..|.:...||:|.|..||..|...: |.:::..||..|.||:|||.|||...|||
 Frog     9 PYPNSTL---EQLVSNVSNTSNASDKPGDAWMVGM-GIIMSCIVLVIVLGNVLVITAIAKFQRLQ 69

Human    70 TMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVD 134
            |:||.|:||||.|||:|||:|||..|:..:...|......||.|||||:|||||||||||.:|||
 Frog    70 TVTNYFITSLACADLLMGLIVVPFGASSIILDTWVFNNFWCEFWTSVDILCVTASIETLCVIAVD 134

Human   135 RYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFA 199
            ||.|:|:|.||.:|:||..||..::||||||...||.||...|:|: .:..|..|:.:|.||.|.
 Frog   135 RYFAITSPFRYQSLLTKCKARIVILLVWVVSTLTSFLPIYMHWYRI-EEESALHCYDDPSCCFFF 198

Human   200 SNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESPPAPSRSLAPAPVG 264
            :|..|.:.||.:||||||:||:|||||||..|.:||:.:....|||..:.:....:...
 Frog   199 TNPAYAISSSIISFYLPLVVMIFVYARVFQEAKKQLKKIDKSEGRFHNQNNQQDTNGKQ------ 257

Human   265 TCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFL 329
                       |.:......|:||:||.|||:|||||||||||||:.|:::.: ....:|...:.
 Frog   258 -----------GNKRTSKFWLKEHKALKTLGIIMGTFTLCWLPFFIVNIVQVM-HKDFIPVKVYN 310

Human   330 ALNWLGYANSAFNPLIYCRSPDFRSAFRRLLCRCGRRLPPEPCAAARPALFPSGVPAARSSPA-- 392
            .|||:||.||||||||||||||||..|:.|||.      .:|.:.|    :.:|.|.:..:.|
 Frog   311 FLNWVGYVNSAFNPLIYCRSPDFRYTFQELLCL------RKPGSKA----YANGYPQSNGNSAYN 365

Human   393 ---------QPRLCQRL 400
                     :.|.|:.|
 Frog   366 EDTEPCQYSKDRTCEVL 382

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ADRB3	NP_000016.1	7tm_GPCRs	51..356	CDD:475119	152/304 (50%)
		TM helix 2	73..95	CDD:320625	15/21 (71%)
		TM helix 3	111..133	CDD:320625	17/21 (81%)
		TM helix 4	156..172	CDD:320625	8/15 (53%)
		TM helix 5	202..225	CDD:320625	13/22 (59%)
		TM helix 6	291..313	CDD:320625	17/21 (81%)
		TM helix 7	325..350	CDD:320625	16/24 (67%)
adrb2	NP_001116897.2	7tmA_Beta2_AR	38..337	CDD:341355	155/318 (49%)
		TM helix 1	39..65	CDD:341355	12/26 (46%)
		TM helix 2	72..99	CDD:341355	17/26 (65%)
		TM helix 3	110..140	CDD:341355	24/29 (83%)
		TM helix 4	152..175	CDD:341355	12/22 (55%)
		TM helix 5	200..232	CDD:341355	20/31 (65%)
		TM helix 6	267..297	CDD:341355	22/29 (76%)
		TM helix 7	306..331	CDD:341355	16/24 (67%)