DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ADRB3 and adrb2

DIOPT Version :9

Sequence 1:	NP_000016.1	Gene:	ADRB3 / 155	HGNCID:	288	Length:	408	Species:	Homo sapiens
Sequence 2:	NP_001116897.2	Gene:	adrb2 / 100144654	XenbaseID:	XB-GENE-494302	Length:	419	Species:	Xenopus tropicalis

Alignment Length:	407	Identity:	179/407 - (43%)
Similarity:	239/407 - (58%)	Gaps:	44/407 - (10%)

- Green bases have known domain annotations that are detailed below.

Human     5 PHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQ 69
            |:.||:|   ..|.:...||:|.|..||..|...: |.:::..||..|.||:|||.|||...|||
Frog     9 PYPNSTL---EQLVSNVSNTSNASDKPGDAWMVGM-GIIMSCIVLVIVLGNVLVITAIAKFQRLQ 69

Human    70 TMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVD 134
            |:||.|:||||.|||:|||:|||..|:..:...|......||.|||||:|||||||||||.:|||
Frog    70 TVTNYFITSLACADLLMGLIVVPFGASSIILDTWVFNNFWCEFWTSVDILCVTASIETLCVIAVD 134

Human   135 RYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFA 199
            ||.|:|:|.||.:|:||..||..::||||||...||.||...|:|: .:..|..|:.:|.||.|.
Frog   135 RYFAITSPFRYQSLLTKCKARIVILLVWVVSTLTSFLPIYMHWYRI-EEESALHCYDDPSCCFFF 198

Human   200 SNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESPPAPSRSLAPAPVG 264
            :|..|.:.||.:||||||:||:|||||||..|.:||:.:....|||..:.:....:...
Frog   199 TNPAYAISSSIISFYLPLVVMIFVYARVFQEAKKQLKKIDKSEGRFHNQNNQQDTNGKQ------ 257

Human   265 TCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFL 329
                       |.:......|:||:||.|||:|||||||||||||:.|:::.: ....:|...:.
Frog   258 -----------GNKRTSKFWLKEHKALKTLGIIMGTFTLCWLPFFIVNIVQVM-HKDFIPVKVYN 310

Human   330 ALNWLGYANSAFNPLIYCRSPDFRSAFRRLLCRCGRRLPPEPCAAARPALFPSGVPAARSSPA-- 392
            .|||:||.||||||||||||||||..|:.|||.      .:|.:.|    :.:|.|.:..:.|
Frog   311 FLNWVGYVNSAFNPLIYCRSPDFRYTFQELLCL------RKPGSKA----YANGYPQSNGNSAYN 365

Human   393 ---------QPRLCQRL 400
                     :.|.|:.|
Frog   366 EDTEPCQYSKDRTCEVL 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ADRB3	NP_000016.1	7tm_GPCRs	51..356	CDD:333717	152/304 (50%)
		TM helix 2	73..95	CDD:320095	15/21 (71%)
		TM helix 3	111..133	CDD:320095	17/21 (81%)
		TM helix 4	156..172	CDD:320095	8/15 (53%)
		TM helix 5	202..225	CDD:320095	13/22 (59%)
		TM helix 6	288..313	CDD:320095	19/24 (79%)
		TM helix 7	325..350	CDD:320095	16/24 (67%)
adrb2	NP_001116897.2	7tmA_Beta2_AR	38..337	CDD:341355	155/318 (49%)
		TM helix 1	39..65	CDD:341355	12/26 (46%)
		TM helix 2	72..99	CDD:341355	17/26 (65%)
		TM helix 3	110..140	CDD:341355	24/29 (83%)
		TM helix 4	152..175	CDD:341355	12/22 (55%)
		TM helix 5	200..232	CDD:341355	20/31 (65%)
		TM helix 6	267..297	CDD:341355	22/29 (76%)
		TM helix 7	306..331	CDD:341355	16/24 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276672at33208
OrthoFinder	1	1.000	-	-		FOG0002077
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X822
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920