DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsd17b4 and CG11151

DIOPT Version :9

Sequence 1:	NP_032318.2	Gene:	Hsd17b4 / 15488	MGIID:	105089	Length:	735	Species:	Mus musculus
Sequence 2:	NP_001259531.1	Gene:	CG11151 / 32335	FlyBaseID:	FBgn0030519	Length:	115	Species:	Drosophila melanogaster

Alignment Length:	116	Identity:	55/116 - (47%)
Similarity:	73/116 - (62%)	Gaps:	4/116 - (3%)

- Green bases have known domain annotations that are detailed below.

Mouse   621 LQSALVFGEIGRRLKSVGREVVKKANAVFEWHITKGGTVAAKWTIDLKSGSGEVYQGPAKG-SAD 684
            |||..||.:|...||. .....|..|.||.:.|||.|.||.:||:|.|  :.:.|:|||:| ..|
  Fly     3 LQSDAVFQKIIDGLKE-NEAKAKAVNGVFLYKITKDGKVAKEWTLDCK--NAKAYEGPAQGIKVD 64

Mouse   685 VTIIISDEDFMEVVFGKLDPQKAFFSGRLKARGNIMLSQKLQMILKDYAKL 735
            .|:.::|||.:::..|||:||.||..|:||..|||||:|||..:||..|||
  Fly    65 TTLTVADEDMVDIALGKLNPQAAFMKGKLKIAGNIMLTQKLAPLLKTDAKL 115

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsd17b4	NP_032318.2	(3R)-hydroxyacyl-CoA dehydrogenase	1..305
		hydroxyacyl-CoA-like_DH_SDR_c-like	5..254	CDD:187611
		fabG	6..226	CDD:235546
		Enoyl-CoA hydratase 2	321..621		55/116 (47%)
		PLN02864	329..604	CDD:178455
		hot_dog	<394..443	CDD:294345
		(3R)-3-hydroxydecanoyl-CoA binding. /evidence=ECO:0000250	405..406
		HDE_HSD	484..604	CDD:239532
		(3R)-3-hydroxydecanoyl-CoA binding. /evidence=ECO:0000250	509..514
		SCP2	633..730	CDD:280250	44/97 (45%)
		Microbody targeting signal. /evidence=ECO:0000255	733..735		1/1 (100%)
CG11151	NP_001259531.1	SCP2	9..109	CDD:396566	46/102 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	90	1.000	Domainoid score	I7767
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2120
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.940