Protein Alignment Hspa1l and Hsp70Bb

DIOPT Version :9

• Sequence 1: NP_038586.2
• Gene: Hspa1l / 15482
• MGIID: 96231
• Length: 641
• Species: Mus musculus
• Sequence 2: NP_524927.2
• Gene: Hsp70Bb / 48582
• FlyBaseID: FBgn0013278
• Length: 641
• Species: Drosophila melanogaster
• Alignment Length: 641
• Identity: 475/641 - (74%)
• Similarity: 553/641 - (86%)
• Gaps: 9/641 - (1%)

Mouse     8 AIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPQNTVFDA 72
            |||||||||||||||:|||||||||||||||||||||||||:||||||.|||||||||:||||||
  Fly     3 AIGIDLGTTYSCVGVYQHGKVEIIANDQGNRTTPSYVAFTDSERLIGDPAKNQVAMNPRNTVFDA 67

Mouse    73 KRLIGRKFNDPVVQSDMKLWPFQVINEAGKPKVMVSYKGEKKAFYPEEISSMVLTKMKETAEAFL 137
            |||||||::||.:..|||.|||:|:::.||||:.|.||||.|.|.||||||||||||||||||:|
  Fly    68 KRLIGRKYDDPKIAEDMKHWPFKVVSDGGKPKIGVEYKGESKRFAPEEISSMVLTKMKETAEAYL 132

Mouse   138 GHNVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDKGSHGERHVLIFDL 202
            |.::|:|||||||||||||||||||||.|||||||||||||||||:||||||...|||:||||||
  Fly   133 GESITDAVITVPAYFNDSQRQATKDAGHIAGLNVLRIINEPTAAALAYGLDKNLKGERNVLIFDL 197

Mouse   203 GGGTFDVSILTIDDG-IFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLR 266
            |||||||||||||:| :|||::|||||||||||||||||:|..||||||:|||:..|.||:||||
  Fly   198 GGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVTHLAEEFKRKYKKDLRSNPRALRRLR 262

Mouse   267 TACERAKRTLSSSTQANLEIDSLYEGIDFYTSITRARFEELCADLFRGTLEPVEKSLRDAKMDKA 331
            ||.|||||||||||:|.:|||:|:||.||||.::|||||||||||||.||:||||:|.||||||.
  Fly   263 TAAERAKRTLSSSTEATIEIDALFEGQDFYTKVSRARFEELCADLFRNTLQPVEKALNDAKMDKG 327

Mouse   332 KIHDIVLVGGSTRIPKVQKLLQDYFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSEKVQDLLLL 396
            :|||||||||||||||||.|||::|:|::||.|||||||||||||||||||.||:|.|:||:||:
  Fly   328 QIHDIVLVGGSTRIPKVQSLLQEFFHGKNLNLSINPDEAVAYGAAVQAAILSGDQSGKIQDVLLV 392

Mouse   397 DVAPLSLGLETAGGVMTVLIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTRDNNLLGRF 461
            ||||||||:||||||||.||:||..||.|||:.|:|||||||||.|||||||||||:|||.||.|
  Fly   393 DVAPLSLGIETAGGVMTKLIERNCRIPCKQTKTFSTYSDNQPGVSIQVYEGERAMTKDNNALGTF 457

Mouse   462 DLTGIPPAPRGVPQIEVTFDIDANGILNVTAMDKSTGKANKITITNDKGRLSKEEIERMVQEAER 526
            ||:|||||||||||||||||:||||||||:|.:.|||||..|||.|||||||:.||:|||.|||:
  Fly   458 DLSGIPPAPRGVPQIEVTFDLDANGILNVSAKEMSTGKAKNITIKNDKGRLSQAEIDRMVNEAEK 522

Mouse   527 YKAEDEGQREKIAAKNALESYAFNMKSAVGDEGLKDKISESDKKKILDKCNEVLSWLEANQLAEK 591
            |..|||..|::|.::||||||.||:|.:| ::....|:.|:||..:||||||.:.||::|..|||
  Fly   523 YADEDEKHRQRITSRNALESYVFNVKQSV-EQAPAGKLDEADKNSVLDKCNETIRWLDSNTTAEK 586

Mouse   592 DEFDHKRKELENMCNPIITKLYQSGCTGPTCTPGYTPGRAA------TGPTIEEVD 641
            :|||||.:||...|:||:||::|.| .|....||...|:.|      :|||:||||
  Fly   587 EEFDHKMEELTRHCSPIMTKMHQQG-AGAAGGPGANCGQQAGGFGGYSGPTVEEVD 641

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hspa1l	NP_038586.2	HSP70	3..641	CDD:331774	473/639 (74%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142	3..388		308/380 (81%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142	396..511		91/114 (80%)
Hsp70Bb	NP_524927.2	PTZ00009	2..641	CDD:240227	473/639 (74%)
		HSPA1-2_6-8-like_NBD	3..379	CDD:212675	305/375 (81%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53894
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100083
Panther	1	1.100	-	-	O	PTHR19375
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.820