DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hoxd3 and ftz

DIOPT Version :9

Sequence 1:	NP_034598.2	Gene:	Hoxd3 / 15434	MGIID:	96207	Length:	433	Species:	Mus musculus
Sequence 2:	NP_477498.1	Gene:	ftz / 40834	FlyBaseID:	FBgn0001077	Length:	410	Species:	Drosophila melanogaster

Alignment Length:	409	Identity:	115/409 - (28%)
Similarity:	156/409 - (38%)	Gaps:	134/409 - (32%)

- Green bases have known domain annotations that are detailed below.

Mouse    21 AYYENPGLFGGY----GYSKATDTYGYST----------PHQP-YPPPAAANSLDSDYPSSACSI 70
            |||:|...:.||    .||::  .|.|:.          |.|| .|||.|......|..:|..:.
  Fly    39 AYYQNTSNYQGYYPQESYSES--CYYYNNQEQVTTQTVPPVQPTTPPPKATKRKAEDDAASIIAA 101

Mouse    71 QSSAP--LRA------------PAHKGAELNGSCMRPGTGNSQGGGGGNQPPGLNSEQQPPQPPP 121
            ....|  |||            |.:....:......|......     ...|..:.:|:....|.
  Fly   102 VEERPSTLRALLTNPVKKLKYTPDYFYTTVEQVKKAPAVSTKV-----TASPAPSYDQEYVTVPT 161

Mouse   122 P----------------------------PPPTLPPSSPTNPGSGVPAKKTKGGLSASSSSSTIS 158
            |                            ||||.|.|.|...|...| .::.|..|:|:.|..|:
  Fly   162 PSASEDVDYLDVYSPQSQTQKLKNGDFATPPPTTPTSLPPLEGISTP-PQSPGEKSSSAVSQEIN 225

Mouse   159 KQI---------FPW--MKESRQNSKQKNSCATSGENCEDKSPPGPASKRVRTAYTSAQLVELEK 212
            .:|         |.|  ::|            |...:|:|       |||.|..||..|.:||||
  Fly   226 HRIVTAPNGAGDFNWSHIEE------------TLASDCKD-------SKRTRQTYTRYQTLELEK 271

Mouse   213 EFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYKKDQKAKGILHSPAGQSPERSPPLGGA 277
            |||||||:.|.||:::||.|:|:||||||||||||||.|||            ::.:.||...||
  Fly   272 EFHFNRYITRRRRIDIANALSLSERQIKIWFQNRRMKSKKD------------RTLDSSPEHCGA 324

Mouse   278 AGHVAYSGQLPPVPGL------AYDAPSP-----------PAFAKSQPNMYGL-----AAYTAPL 320
                .|:..|||:...      |...|.|           ||::.|..:.|||     ...|...
  Fly   325 ----GYTAMLPPLEATSTATTGAPSVPVPMYHHHQTTAAYPAYSHSHSHGYGLLNDYPQQQTHQQ 385

Mouse   321 SSCLPQQKRYPAPEFEPHP 339
            ....|||.::.. .::.||
  Fly   386 YDAYPQQYQHQC-SYQQHP 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hoxd3	NP_034598.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	44..198		42/217 (19%)
		Antp-type hexapeptide	161..166		3/15 (20%)
		Homeobox	199..251	CDD:278475	36/51 (71%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	258..280		4/21 (19%)
		DUF4074	370..431	CDD:290032
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	401..433
ftz	NP_477498.1	FTZ	1..248	CDD:281812	48/228 (21%)
ftz	NP_477498.1	Homeobox	257..310	CDD:278475	36/52 (69%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	107	1.000	Inparanoid score	I4905
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.860