Protein Alignment CYP1A1 and Cyp6a22

DIOPT Version :9

• Sequence 1: NP_000490.1
• Gene: CYP1A1 / 1543
• HGNCID: 2595
• Length: 512
• Species: Homo sapiens
• Sequence 2: NP_001286431.1
• Gene: Cyp6a22 / 49847
• FlyBaseID: FBgn0013773
• Length: 499
• Species: Drosophila melanogaster
• Alignment Length: 554
• Identity: 134/554 - (24%)
• Similarity: 220/554 - (39%)
• Gaps: 138/554 - (24%)

Human    14 LASVIFCLVFWVIRASRPQ-VPKGLKNPPGPWGWPLIGHMLTLGKNPHL--ALSRMSQQY----- 70
            |..:...:.||.:|..... ..:|:.:.|..:.   :|:|....||.|.  .::.:.:::
  Fly     7 LLLIALAVGFWFVRTRYSYWTRRGIGSEPARFP---VGNMEGFRKNKHFIDIVTPIYEKFKGNGA 68

Human    71 ---GDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKG-------RPDLYTFTLISNGQSMSFSP 125
               |..:.:|    |||:::.|:..:|.|::...:|:.       |.|..|..|        |..
  Fly    69 PFAGFFMMLR----PVVLVTDLELAKQILIQDFANFEDRGMYHNERDDPLTGHL--------FRI 121

Human   126 DSGPVWAARRRLAQNGLKSFSIAS-DPASSTSCYLEEHVSKEAEVL-------ISTLQELMAGPG 182
            | ||.|   |.|.|....:|:.|. .....|.|.:.|.:::....|       |..:.:|||
  Fly   122 D-GPKW---RPLRQKMSPTFTSAKMKYMFPTVCEVGEELTQVCGELADNAMCGILEIGDLMA--- 179

Human   183 HFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPA------------- 234
                 ||    .::||....||          :....|.|...|....|..|
  Fly   180 -----RY----TSDVIGRCAFG----------VECNGLRNPEAEFAIMGRRAFSERRHCKLVDGF 225

Human   235 --DFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIR-DITDSLIEHCQEKQLDE 296
              .|..:.|:|....::  :|:.:.:...:::.||:..   |:|.:| |..:.|||   .||..|
  Fly   226 IESFPEVARFLRMRQIH--QDITDFYVGIVRETVKQRE---EQGIVRSDFMNLLIE---MKQRGE 282

Human   297 NANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRL-- 359
                 |:.|::.......|.|||||..:.:.::|..|...|.:|.|::||:|..:      ||
  Fly   283 -----LTIEEMAAQAFIFFAAGFDTSASTLGFALYELAKQPALQAKLREEIDQAL------RLHN 336

Human   360 -----SDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDT----SLKG---FYIPKGRCVFVNQW 412
                 .....|.|||..|.||.|....:|     ..||.:    :.||   |||..|:.:.:..:
  Fly   337 GEFTYDSMQELRYMELVIAETLRKYPILP-----QLTRISRHLYAAKGDRHFYIEPGQMLLIPVY 396

Human   413 QINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKV---IIFGMGKRKCIGETIARWEVFLFLAIL 474
            .|:||..|:..|.:|:|||||.     |::.....   :.||.|.|.|||....:.:..:.|..|
  Fly   397 GIHHDPALYPEPHKFIPERFLA-----DQLAQRPTAAWLPFGDGPRNCIGMRFGKMQTTIGLVSL 456

Human   475 LQRVEFSV-----P----LGVKVDMTPIYGLTMK 499
            |:...|||     |    |...:.:.|..|:.:|
  Fly   457 LRNFHFSVCPRTDPKIEFLKSNILLCPANGIYLK 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP1A1	NP_000490.1	Mitochondrial targeting signal. /evidence=ECO:0000250|UniProtKB:P00185	29..40		1/11 (9%)
		p450	40..499	CDD:365848	128/525 (24%)
Cyp6a22	NP_001286431.1	p450	35..491	CDD:278495	129/526 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4074
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.950