DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CYP1A1 and Cyp303a1

DIOPT Version :9

Sequence 1:	NP_000490.1	Gene:	CYP1A1 / 1543	HGNCID:	2595	Length:	512	Species:	Homo sapiens
Sequence 2:	NP_001285977.1	Gene:	Cyp303a1 / 49165	FlyBaseID:	FBgn0001992	Length:	503	Species:	Drosophila melanogaster

Alignment Length:	521	Identity:	144/521 - (27%)
Similarity:	226/521 - (43%)	Gaps:	81/521 - (15%)

- Green bases have known domain annotations that are detailed below.

Human    18 IFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGK--------------------NPHLA 62
            |||.....|.....:.||  :.||||..:|::|..|.:.:                    ||:
  Fly     8 IFCATLLAILFGGVRKPK--RFPPGPAWYPIVGSALQVSQLRCRLGMFCKVIDVFARQYVNPY-- 68

Human    63 LSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDS 127
                 ..||    ::||...||:....|.|.:.:.  .:|..||||...:.|.:....:......
  Fly    69 -----GFYG----LKIGKDKVVIAYTNDAISEMMT--NEDIDGRPDGIFYRLRTFNSRLGVLLTD 122

Human   128 GPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPG----HFNPYR 188
            |.:|..:||.....||:|..|...       :.:.|..||..|:..|::.:...|    ....:.
  Fly   123 GEMWVEQRRFILRHLKNFGFARSG-------MMDIVHNEATCLLQDLKDKVLKSGGKQTRIEMHD 180

Human   189 YVVVSVTNVICAICFGRRYDHNHQELLSLV----NLNNNFGEVVGSGNPADFIPILRYL-PNPS- 247
            ...|.|.|.:..:..||||:....|:..|:    .|..|...|   |......|:||:: ||.|
  Fly   181 LTSVYVLNTLWCMLSGRRYEPGSPEITQLLETFFELFKNIDMV---GALFSHFPLLRFIAPNFSG 242

Human   248 LNAFKDLNEKFYSFMQKMVKEH---YKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIIN 309
            .|.|.:.:...|:||.|.::.|   ||.:::.  ||:.||.: ..|::..||..  ..||:.::.
  Fly   243 YNGFVESHRSLYTFMSKEIELHRLTYKNYDEP--RDLMDSYL-RAQDEGNDEKG--MFSDQSLLA 302

Human   310 IVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLS-DRSHLPYMEAFIL 373
            |.||:|.||.:|...::.:..|:||:.|.:|.:..:|:..|:|..|.|..| ||:.|||.||..|
  Fly   303 ICLDMFLAGSETTNKSLGFCFMHLVLQPEIQERAFQEIKEVVGLERIPEWSRDRTKLPYCEAITL 367

Human   374 ETFRHSSFVPFTIPHSTTRDTSLKGFYIPKG-------RCVFVNQWQINHDQKLWVNPSEFLPER 431
            |..|......|.|||....||.|.|:.|||.       |.:.:|...       :.:|..|.|:|
  Fly   368 EAVRMFMLHTFGIPHRAVCDTRLSGYEIPKDTMVIACFRGMLINPVD-------FPDPESFNPDR 425

Human   432 FLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDMTPIYGL 496
            :|. ||.:.  |.|....||.|:.:|:|:.:.|..:|:|...:||..:.....|...:..|:.|.
  Fly   426 YLF-DGHLK--LPEAFNPFGFGRHRCMGDLLGRQNLFMFTTTVLQNFKMVAIPGQVPEEVPLEGA 487

Human   497 T 497
            |
  Fly   488 T 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP1A1	NP_000490.1	Mitochondrial targeting signal. /evidence=ECO:0000250\|UniProtKB:P00185	29..40		2/10 (20%)
CYP1A1	NP_000490.1	p450	40..499	CDD:365848	138/499 (28%)
Cyp303a1	NP_001285977.1	p450	28..480	CDD:278495	135/489 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920