DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hoxd1 and Scr

DIOPT Version :9

Sequence 1:	NP_034597.2	Gene:	Hoxd1 / 15429	MGIID:	96201	Length:	328	Species:	Mus musculus
Sequence 2:	NP_001368995.1	Gene:	Scr / 40833	FlyBaseID:	FBgn0003339	Length:	564	Species:	Drosophila melanogaster

Alignment Length:	262	Identity:	75/262 - (28%)
Similarity:	103/262 - (39%)	Gaps:	58/262 - (22%)

- Green bases have known domain annotations that are detailed below.

Mouse    39 ALQPAFPLGSGDGAFVSC---LPLATARPTPSPPAGPAQSPVPQPAAPRYAPCTLEGAYERGAAP 100
            |..|..|.|||.|.....   ...|.:....|......|....:..:|:.:|.::..:..|
  Fly   170 ANDPVTPGGSGGGGVSGSNNNNNSANSNNNNSQSLASPQDLSTRDISPKLSPSSVVESVAR---- 230

Mouse   101 ASAAEYGFLGSGPAFDFPGALGRAADEGGAHVHYATSAVFSGGGSFLLSGQVDFAAFGEPGPFPA 165
              :...|.||        |:|..||...|.:.:::.|.| |||                ||....
  Fly   231 --SLNKGVLG--------GSLAAAAAAAGLNNNHSGSGV-SGG----------------PGNVNV 268

Mouse   166 CLKEPADGHPGPFQTVSPAPGACPKPASPTSSLPAAHSTFEWMK--------VKRNAPKKSKLSE 222
            .:..|..|............|:.....:...:.|   ..:.|||        |..|...|.:
  Fly   269 PMHSPGGGDSDSESDSGNEAGSSQNSGNGKKNPP---QIYPWMKRVHLGTSTVNANGETKRQ--- 327

Mouse   223 YGATSPPSAIRTNFSTKQLTELEKEFHFNKYLTRARRIEIANCLQLNDTQVKIWFQNRRMKQKKR 287
                      ||:::..|..|||||||||:||||.||||||:.|.|.:.|:||||||||||.||.
  Fly   328 ----------RTSYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKE 382

Mouse   288 ER 289
            .:
  Fly   383 HK 384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hoxd1	NP_034597.2	PRK04233	59..>105	CDD:305134	6/45 (13%)
		Antp-type hexapeptide	204..209		1/4 (25%)
		Homeobox	233..285	CDD:278475	35/51 (69%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	304..328
Scr	NP_001368995.1	Homeobox	328..381	CDD:395001	35/52 (67%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X14
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810