DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hoxb3 and HGTX

DIOPT Version :9

Sequence 1:	NP_001073338.1	Gene:	Hoxb3 / 15410	MGIID:	96184	Length:	433	Species:	Mus musculus
Sequence 2:	NP_001368954.1	Gene:	HGTX / 53446	FlyBaseID:	FBgn0040318	Length:	587	Species:	Drosophila melanogaster

Alignment Length:	477	Identity:	94/477 - (19%)
Similarity:	129/477 - (27%)	Gaps:	215/477 - (45%)

- Green bases have known domain annotations that are detailed below.

Mouse     2 QKATYYDNTAAALF-------------GGYSSYP-----GSNGFGY---DGPPQPPFQAATHLEG 45
            |.|.|:...|||..             ...:|.|     .::|.|.   |.|...|..|::.|..
  Fly   128 QLADYHSAAAAAAVYANNNNNNNNNSSNNNNSSPLMLLKAAHGGGLKDSDSPSTTPPPASSRLHS 192

Mouse    46 DYQRSACSLQSLGNAAPHAKSKELNGSCMRPGLAPEPL-PAPPGSPPPSA----APTSTTS---- 101
            |   |:.|.:...|::|...|.:......|...|.:|. .:...||||..    :|.:.:|
  Fly   193 D---SSPSPRYEHNSSPGVDSAKSYALSQRSSGAEDPCQTSESASPPPQGQNDYSPENLSSQRAK 254

Mouse   102 -------------NSNNGGGP---------------SKSGPPKCGAGSNSTLTKQIFPWMKESRQ 138
                         |:|:.|.|               |..|||.....|.:|..|
  Fly   255 FQHHHGVNPLALHNANHAGNPGCHNNNNHMDHKLPLSFLGPPLAALHSMTTEMK----------- 308

Mouse   139 TSKLKNSSPGTAEGCGGGGGGGGG---------------GGGGGGGSS--------GGGGGGGGG 180
                       .:|.||......|               |.||...||        ..|.....|
  Fly   309 -----------GQGVGGSSASANGLSYSHSPNSHLISDRGSGGSSSSSSTTTTNTNSQGAPNPHG 362

Mouse   181 GD----KSPPGSAA--------------------------------------------------- 190
            .|    |.||.::|
  Fly   363 IDTILSKPPPVTSAGLSALTGAGIPRFSIAAAAAGMAQYLSQSQGAPLKTHAGHIVDRTHLYWPG 427

Mouse   191 --------------------------------------SKRARTAYTSAQLVELEKEFHFNRYLC 217
                                                  .|..|..::..|:..|||.|...:||.
  Fly   428 LQGLVANPIAWRERLSNTMSANLSQSHQHHPSNDKDGKKKHTRPTFSGQQIFALEKTFEQTKYLA 492

Mouse   218 RPRRVEMANLLNLSERQIKIWFQNRRMKYKKDQ-----KAKGLASSSGGPSPAGSPPQPMQSTAG 277
            .|.|.::|..|.:||.|:|:||||||.|::|..     .||......||.:. |...:.|.|.
  Fly   493 GPERAKLAYALGMSESQVKVWFQNRRTKWRKRHAAEMATAKRKQDDMGGDND-GDCSETMDSD-- 554

Mouse   278 FMNALHSMTPSYDSPSPPAFGK 299
                    ..|.|....||..|
  Fly   555 --------NESLDMGESPAQNK 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hoxb3	NP_001073338.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	63..124		19/97 (20%)
		Antp-type hexapeptide	129..134		0/4 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	136..195		17/174 (10%)
		Homeobox	195..248	CDD:365835	23/52 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	249..276		7/31 (23%)
		DUF4074	369..431	CDD:372548
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	389..433
HGTX	NP_001368954.1	ROM1	179..>388	CDD:227709	46/233 (20%)
HGTX	NP_001368954.1	Homeobox	469..523	CDD:395001	23/53 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X14
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000