DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hoxb3 and toy

DIOPT Version :9

Sequence 1:	NP_001073338.1	Gene:	Hoxb3 / 15410	MGIID:	96184	Length:	433	Species:	Mus musculus
Sequence 2:	NP_001368990.1	Gene:	toy / 43833	FlyBaseID:	FBgn0019650	Length:	655	Species:	Drosophila melanogaster

Alignment Length:	384	Identity:	79/384 - (20%)
Similarity:	125/384 - (32%)	Gaps:	138/384 - (35%)

- Green bases have known domain annotations that are detailed below.

Mouse    91 PPSAAPTSTTSNSNNGGGPSKSGPPKCGAGSNSTLTKQIFPWMKESRQTSKLKNSSPGTAEGCGG 155
            ||:|:..::.:|.:             |......:.|:...:..|...|:...::|.|.:|
  Fly   199 PPAASVVTSPANLS-------------GQADRDDVQKRELQFSVEVSHTNSHDSTSDGNSE---- 246

Mouse   156 GGGGGGGGGGGGGGSSGGGGGGGGGGDKSPPGSAASKRA----RTAYTSAQLVELEKEFHFNRYL 216
                                 ....||:........||.    ||::::.|:..|||||....|.
  Fly   247 ---------------------HNSSGDEDSQMRLRLKRKLQRNRTSFSNEQIDSLEKEFERTHYP 290

Mouse   217 CRPRRVEMANLLNLSERQIKIWFQNRRMKYKKDQKAK------------GLASSSGGPS---PAG 266
            ....|..:|:.:.|.|.:|::||.|||.|:::::|.:            |..|::..||   .:.
  Fly   291 DVFARERLADKIGLPEARIQVWFSNRRAKWRREEKMRTQRRSADTVDGSGRTSTANNPSGTTASS 355

Mouse   267 SPPQPMQSTAGFMNALHSMTPSYDSPSPPAFGKGHQNAYALPSNYQPPLKGCGAPQKYPPTPASE 331
            |......||.|.:|:              |.....:.:.||.||               ..|.:.
  Fly   356 SVATSNNSTPGIVNS--------------AINVAERTSSALVSN---------------SLPEAS 391

Mouse   332 YEPHVLQANGGAYGTPTMQGSPVYVGGGGYADPLPP--PAGPSLYGLNHLSH---HPSGNLDYNG 391
            ..|.||  .|.|..|.|...||          ||.|  |..|...|.|.:..   .|...:..|.
  Fly   392 NGPTVL--GGEANTTHTSSESP----------PLQPAAPRLPLNSGFNTMYSSIPQPIATMAENY 444

Mouse   392 AAPMG-------------PNQHHGP----------------CDPHPTYTDLSSHHAPPQ 421
            .:.:|             |...|.|                |:|.      ::|..|||
  Fly   445 NSSLGSMTPSCLQQRDAYPYMFHDPLSLGSPYVSAHHRNTACNPS------AAHQQPPQ 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hoxb3	NP_001073338.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	63..124		5/32 (16%)
		Antp-type hexapeptide	129..134		0/4 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	136..195		8/62 (13%)
		Homeobox	195..248	CDD:365835	20/52 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	249..276		7/41 (17%)
		DUF4074	369..431	CDD:372548	15/85 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	389..433		11/62 (18%)
toy	NP_001368990.1	PAX	29..153	CDD:128645
		COG5576	<253..368	CDD:227863	31/114 (27%)
		Homeobox	269..322	CDD:395001	20/52 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910