DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hoxb3 and ro

DIOPT Version :9

Sequence 1:	NP_001073338.1	Gene:	Hoxb3 / 15410	MGIID:	96184	Length:	433	Species:	Mus musculus
Sequence 2:	NP_524521.1	Gene:	ro / 43234	FlyBaseID:	FBgn0003267	Length:	350	Species:	Drosophila melanogaster

Alignment Length:	276	Identity:	69/276 - (25%)
Similarity:	92/276 - (33%)	Gaps:	103/276 - (37%)

- Green bases have known domain annotations that are detailed below.

Mouse     8 DNTAAALFGGYSSYPGSNGFGYDGPPQPPFQAATHLEGDYQRSACSLQSLGNAAPHAKSKELNGS 72
            :.|:.|.:..|..|    |...|.|..|..|...|....:.......|.|...:|
  Fly    95 ERTSLAAYPAYDFY----GHAKDYPQHPSQQHQQHHHHHHHPPQLVHQKLSYVSP---------- 145

Mouse    73 CMRPGLAPEPLPAPPGSPP--PSAAPTSTTSNSNNGGGPSKSGPPKCGAGSNSTLTKQIFPWMKE 135
                   |..:.|...:.|  |.|.|         .|.||   .|...||.::.|.::   ..||
  Fly   146 -------PPAIAAGGAANPVLPHAFP---------AGFPS---DPHFSAGFSAFLARR---RRKE 188

Mouse   136 SRQTSKLKNSSPGTAEGCGGGGGGGGGGGGGGGGSSGGGGGGGGGGDKSPPGSAASKRARTAYTS 200
            .||                                                     :|.||.:::
  Fly   189 GRQ-----------------------------------------------------RRQRTTFST 200

Mouse   201 AQLVELEKEFHFNRYLCRPRRVEMANLLNLSERQIKIWFQNRRMKYKKDQKAK------------ 253
            .|.:.||.|||.|.|:.|.||.|:|..|.|:|.||||||||||.|.|:.:||:
  Fly   201 EQTLRLEVEFHRNEYISRSRRFELAETLRLTETQIKIWFQNRRAKDKRIEKAQIDQHYRNFVVAN 265

Mouse   254 GLASSSGGPSPAGSPP 269
            |..||..|.:....||
  Fly   266 GFMSSIMGQAATTMPP 281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hoxb3	NP_001073338.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	63..124		12/62 (19%)
		Antp-type hexapeptide	129..134		0/4 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	136..195		3/58 (5%)
		Homeobox	195..248	CDD:365835	29/52 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	249..276		8/33 (24%)
		DUF4074	369..431	CDD:372548
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	389..433
ro	NP_524521.1	Homeobox	196..247	CDD:278475	28/50 (56%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810