Protein Alignment Hoxb3 and Hmx

DIOPT Version :10

• Sequence 1: NP_034588.2
• Gene: Hoxb3 / 15410
• MGIID: 96184
• Length: 433
• Species: Mus musculus
• Sequence 2: NP_001262674.1
• Gene: Hmx / 42110
• FlyBaseID: FBgn0264005
• Length: 718
• Species: Drosophila melanogaster
• Alignment Length: 529
• Identity: 121/529 - (22%)
• Similarity: 168/529 - (31%)
• Gaps: 165/529 - (31%)

Mouse     8 DNTAAALFGGYSSYPGSNGF---------------------GYDGP-PQPPFQAATHLEGDYQRS 50
            |:..::..||..|..|||||                     |...| ||.|...|    |..| .
  Fly   212 DSNGSSGGGGGKSTTGSNGFTSFSISSILSRSEPAKKNGAAGLITPIPQLPQPGA----GGPQ-D 271

Mouse    51 ACSLQSLGNAAPHAKSKELNGSCMRPGLAPEPLPAPPGSPPPSAAPTSTT-----------SNSN 104
            |..|..||..:..........:...||....|...|..||...::.|:||           :|:|
  Fly   272 AAMLSRLGFISQWGALAGRYAALCPPGWPWAPQRLPFHSPTHDSSSTNTTENPPSPTSMSPNNNN 336

Mouse   105 NGGGPSKSGPPKCGAGSNSTLTKQIFPWMKESRQTSKLKNS------------------SPGTAE 151
            |....:.|......:.|:..|.....|...:.:|..:.::.                  .|.|..
  Fly   337 NNSNTTASSNQASKSPSHHPLHPLYHPLGSQQQQQQQQQHQQHPQQQQHPQQQQQQHPHQPTTPT 401

Mouse   152 GCGGGGGGG-----------GGGGG----GGGGSSGGGG--------GGGGGGDKSPP----GSA 189
            .....|||.           |..||    .....|...|        |..|..|.|.|    .|.
  Fly   402 SSSSSGGGSSLTHHPHPHLTGSHGGYLLPSSSNESDEEGEEIIEEDDGTDGPSDSSSPHGDGNSK 466

Mouse   190 ASKRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLSERQIKIWFQNRRMKYKKDQKAKG 254
            ..|:.||.::.||:.:||..|...|||....|..:|..|.|:|.|:||||||||.|:|:...|:.
  Fly   467 RKKKTRTVFSRAQVFQLESTFDLKRYLSSSERAGLAASLRLTETQVKIWFQNRRNKWKRQLAAEL 531

Mouse   255 LASSSGGPSPAGSPPQPMQ------STAGFMNALHSMTPSYDSPSPPAFGKGHQNA---YALPSN 310
            .|::....:.|......:.      :||||:            |.||.    |.:.   ||...|
  Fly   532 EAANMANMAHAAQRLVRVPVLYHDGTTAGFV------------PPPPP----HHHPMQYYAAARN 580

Mouse   311 YQPPLK---------GCGAPQKYPPTPASEYEPHVLQANGGAYGTPTMQGSPVYVGGGGYADPLP 366
            ..||..         ||.|     ..|.|..:|            |.....|.:        |.|
  Fly   581 TSPPRPPLSSLVXGVGCLA-----TAPMSLLKP------------PNSMAHPPH--------PQP 620

Mouse   367 PPAGP------SLYGLNHL--------SHHPSGNL--DYNGAAPMGPNQHHGPCDPHPTYTDLSS 415
            ||..|      |..|...|        |.....::  |.:.|..:..::......|.|:.|
  Fly   621 PPPAPLHMQQRSFLGCEQLTETDMDSDSEQERSHMMDDEDAAIDVEADEEQESASPVPSAT---- 681

Mouse   416 HHAPPQGRI 424
               ||:..:
  Fly   682 ---PPKSSL 687

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hoxb3	NP_034588.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	63..124		14/71 (20%)
		Antp-type hexapeptide	129..134		1/4 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	136..195		18/103 (17%)
		Homeodomain	192..248	CDD:459649	26/55 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	249..276		3/32 (9%)
		DUF4074	369..431	CDD:463833	12/72 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	389..433		6/36 (17%)
Hmx	NP_001262674.1	Homeodomain	469..525	CDD:459649	26/55 (47%)