DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hoxb3 and abd-A

DIOPT Version :9

Sequence 1:	NP_001073338.1	Gene:	Hoxb3 / 15410	MGIID:	96184	Length:	433	Species:	Mus musculus
Sequence 2:	NP_732176.1	Gene:	abd-A / 42037	FlyBaseID:	FBgn0000014	Length:	590	Species:	Drosophila melanogaster

Alignment Length:	324	Identity:	86/324 - (26%)
Similarity:	112/324 - (34%)	Gaps:	109/324 - (33%)

- Green bases have known domain annotations that are detailed below.

Mouse    38 QAATHLEGDYQRSACSLQSLGNA-----APHAKSKELNGSCMRPGLAPEP-LPAPPG-------- 88
            |...||....|:......||..|     ..|..||....:....|.|.:. |..||.
  Fly   136 QQQQHLHHQQQQHHHQYSSLSAALQLQQQQHHISKLAAAAVASHGHAHQQLLLTPPSAGNSQAGD 200

Mouse    89 ---SPPPSAAPTSTTSNSNNGGGPSKSGPPKCGAGSNSTL-----------------TKQIFPWM 133
               ||.|||:.:|:...|.|...|..:......:.::|..                 |.:::|::
  Fly   201 SSCSPSPSASGSSSLHRSLNDNSPGSASASASASAASSVAAAAAAAAAAASSSFAIPTSKMYPYV 265

Mouse   134 KE----------------------SRQTSKLKNS----------------------------SPG 148
            ..                      ||.|..:.||                            |..
  Fly   266 SNHPSSHGGLSGMAGFTGLEDKSCSRYTDTVMNSYQSMSVPASASAQFAQFYQHATAAASAVSAA 330

Mouse   149 TAEGCGGGGGGGGGGGGGGGGSSGGGGGGGGG-------------------------GDKSPPGS 188
            :|...|....|........|...|.||.||.|                         ||.:.|..
  Fly   331 SAGAIGVDSLGNACTQPASGVMPGAGGAGGAGIADLPRYPWMTLTDWMGSPFERVVCGDFNGPNG 395

Mouse   189 AASKRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLSERQIKIWFQNRRMKYKKDQKA 252
            ...:|.|..||..|.:|||||||||.||.|.||:|:|:.|.|:||||||||||||||.||:.:|
  Fly   396 CPRRRGRQTYTRFQTLELEKEFHFNHYLTRRRRIEIAHALCLTERQIKIWFQNRRMKLKKELRA 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hoxb3	NP_001073338.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	63..124		17/72 (24%)
		Antp-type hexapeptide	129..134		1/4 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	136..195		20/111 (18%)
		Homeobox	195..248	CDD:365835	36/52 (69%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	249..276		1/4 (25%)
		DUF4074	369..431	CDD:372548
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	389..433
abd-A	NP_732176.1	Homeobox	402..454	CDD:278475	36/51 (71%)
abd-A	NP_732176.1	Abdominal-A	456..478	CDD:289192	1/4 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810