DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hoxb3 and lms

DIOPT Version :9

Sequence 1:	NP_001073338.1	Gene:	Hoxb3 / 15410	MGIID:	96184	Length:	433	Species:	Mus musculus
Sequence 2:	NP_001286635.1	Gene:	lms / 37322	FlyBaseID:	FBgn0034520	Length:	378	Species:	Drosophila melanogaster

Alignment Length:	317	Identity:	82/317 - (25%)
Similarity:	123/317 - (38%)	Gaps:	69/317 - (21%)

- Green bases have known domain annotations that are detailed below.

Mouse   135 ESRQTSKLKNSSPGTAEGCGGGGGGGGGGGGGGGGSS----------------GGGGGGGGGGDK 183
            |.|.::..::|   ..:..|.||...|........:|                ....|.|.|.|:
  Fly    24 EMRSSTSFEDS---VQDESGRGGNCLGASRASSPATSSCLDDNMDDGKSDIDLASDDGNGLGDDR 85

Mouse   184 SPPGSAASKRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLSERQIKIWFQNRRMKYKK 248
                   .||.|||:::||:..||.||...:||...:|..:|..|.|:|.||||||||||.|:|:
  Fly    86 -------KKRPRTAFSAAQIKALETEFERGKYLSVAKRTALAKQLQLTETQIKIWFQNRRTKWKR 143

Mouse   249 --DQKAKGLASSSGGPSPAGSPPQPMQSTAGFMNALHSMTPSYDSPSPPAFGKGHQNAYALPSNY 311
              ....:.|||........|...:||  ..|....|.|.||:..:|.......|..:|..:.|
  Fly   144 KYTSDVETLASHYYAQLGIGGLARPM--VVGDRLWLFSQTPTGPTPIQSIMLNGSGSAAPMAS-- 204

Mouse   312 QPPLKGCGAPQK-------YPPTPASEYEPHVLQANGGAYGTPTMQGSPVYVGGGGYADPL---P 366
              .....|:|.:       .||.|.    |.|:::   |......:|.|:     .:|.|.   .
  Fly   205 --ATTATGSPMRPYATSGGMPPLPG----PSVMES---ARNAILARGQPL-----NFALPFGVAK 255

Mouse   367 PPAG--PSLYGLNHLSHHPSGNLDYNGAAPMGPNQHHGPCDPHPTYTDLSSHHAPPQ 421
            ||||  |:...:.....:.:..:||  ||.:..|:         :|..:.....||:
  Fly   256 PPAGGVPAASYIPRCKPYATSYVDY--AASLPTNE---------SYLQMKYATLPPE 301

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hoxb3	NP_001073338.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	63..124
		Antp-type hexapeptide	129..134
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	136..195		13/74 (18%)
		Homeobox	195..248	CDD:365835	27/52 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	249..276		6/26 (23%)
		DUF4074	369..431	CDD:372548	11/55 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	389..433		7/33 (21%)
lms	NP_001286635.1	Cnd2	33..>106	CDD:303063	20/82 (24%)
lms	NP_001286635.1	Homeobox	89..142	CDD:278475	27/52 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X14
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910