DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hoxb3 and unpg

DIOPT Version :9

Sequence 1:	NP_001073338.1	Gene:	Hoxb3 / 15410	MGIID:	96184	Length:	433	Species:	Mus musculus
Sequence 2:	NP_477146.1	Gene:	unpg / 35942	FlyBaseID:	FBgn0015561	Length:	485	Species:	Drosophila melanogaster

Alignment Length:	403	Identity:	102/403 - (25%)
Similarity:	141/403 - (34%)	Gaps:	126/403 - (31%)

- Green bases have known domain annotations that are detailed below.

Mouse    32 PPQPPFQA-------------------------------------ATHLEGDYQRSACSLQSLGN 59
            ||.||..|                                     |..:..||..|......|.:
  Fly   133 PPHPPTHALEKQLPPTLPHPLDTRFLPFNPAAAGVAPTDLSYRRLAELMNQDYVHSLSVHARLQH 197

Mouse    60 AAPHAKSKELNGSCMRPGLAPEPLPAPPGSPPPSAAPTSTTSNSNNGGGPSKSGPP--------- 115
            .|...:..|...:   ||:|....|.||.:                ...|:|||..
  Fly   198 MAAAGRMHEDQAN---PGMAQLQEPTPPQA----------------HSSPAKSGSHSPMEPALDV 243

Mouse   116 ------KCGAGSNSTLTKQIFP-----WMKESRQTSKLKNSSPGTAEGCGGGGGGGGGGGGGGGG 169
                  :|...|.|.::..:.|     .|.:||..:...:.|    |.|....|......|||.|
  Fly   244 GMDEDFECSGDSCSDISLTMSPRNYNGEMDKSRNGAYTNSDS----EDCSDDEGAQSRHEGGGMG 304

Mouse   170 SSGGGGGGGGGGDKSPPGSAASKRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLSERQ 234
            .....|.|.....|       |:|.|||:||.||:|||:|||..:||....|.::|..|.|||.|
  Fly   305 GKDSQGNGSSSNSK-------SRRRRTAFTSEQLLELEREFHAKKYLSLTERSQIATSLKLSEVQ 362

Mouse   235 IKIWFQNRRMKYKKDQKAKGLASSSGGPSPAGSPPQPMQSTAGFMNALHSMTPSYDSPSPPAFGK 299
            :||||||||.|:|: .|| ||.|...|.:         .:|:|....:         |.|.
  Fly   363 VKIWFQNRRAKWKR-VKA-GLTSHGLGRN---------GTTSGTKIVV---------PIPV---- 403

Mouse   300 GHQNAYALPSNYQPPLKGCGAPQKYPPTPASEYEPHVL---QANGGAYGTPTMQGSPVYVGGG-- 359
             |.|.:|:.|.:|...|.|.:..|  |....:.....:   :...|:....:..|.||.:|.|
  Fly   404 -HVNRFAVRSQHQQLEKMCLSGPK--PDLRKKLSAEAIGGFEKFSGSTNASSPSGGPVGLGVGVG 465

Mouse   360 -------GYADPL 365
                   |.:.||
  Fly   466 VGVGVGLGVSTPL 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hoxb3	NP_001073338.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	63..124		13/75 (17%)
		Antp-type hexapeptide	129..134		1/9 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	136..195		15/58 (26%)
		Homeobox	195..248	CDD:365835	31/52 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	249..276		6/26 (23%)
		DUF4074	369..431	CDD:372548
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	389..433
unpg	NP_477146.1	Homeobox	324..375	CDD:278475	30/50 (60%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X14
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810