DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hoxb3 and cad

DIOPT Version :9

Sequence 1:	NP_001073338.1	Gene:	Hoxb3 / 15410	MGIID:	96184	Length:	433	Species:	Mus musculus
Sequence 2:	NP_001260641.1	Gene:	cad / 35341	FlyBaseID:	FBgn0000251	Length:	445	Species:	Drosophila melanogaster

Alignment Length:	403	Identity:	98/403 - (24%)
Similarity:	138/403 - (34%)	Gaps:	130/403 - (32%)

- Green bases have known domain annotations that are detailed below.

Mouse     6 YYD-----NTAAALFGGYSSYPGS---NGFGYDGPP---QPPFQAATHLEGDYQRSACSLQSLGN 59
            ||:     ::|||...|....|.|   :.|..:.|.   |...|...|.......||.|..|...
  Fly    65 YYNSHHMFHSAAAASAGEWHSPASSTADNFVQNVPTSAHQLMQQHHHHHAHASSSSASSGSSSSG 129

Mouse    60 AAPHA-KSKELNGSC----------------MRPGLAP--------EPLPAP-----------PG 88
            .||.| :..|.|.|.                ..||.||        |.||:|           ||
  Fly   130 GAPGAPQLNETNSSIGVGGAGGGGGVGGATDGGPGSAPPNHQQHIAEGLPSPPITVSGSEISSPG 194

Mouse    89 SPPPSAAP-------TSTTSNSNNGGGPSKSGPPKCGAGSNSTLTKQ----------IFPWMKES 136
            :|..:::|       .|..:|:||....:.:.|......:|:.....          .|.|||:.
  Fly   195 APTSASSPHHHLAHHLSAVANNNNNNNNNNNSPSTHNNNNNNNSVSNNNRTSPSKPPYFDWMKKP 259

Mouse   137 RQTSKLK---NSSPGTAEGCGGGGGGGGGGGGGGGGSSGGGGGGGGGGDKSPPGSAASK-----R 193
            ...::.:   :|||...                               |.|....|:.|     :
  Fly   260 AYPAQPQPDLSSSPNLE-------------------------------DLSDLLDASGKTRTKDK 293

Mouse   194 ARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLSERQIKIWFQNRRMKYKKDQKAKGLASS 258
            .|..||..|.:|||||:..:||:...|:.|:|..|:|||||:||||||||.|.:|..|
  Fly   294 YRVVYTDFQRLELEKEYCTSRYITIRRKSELAQTLSLSERQVKIWFQNRRAKERKQNK------- 351

Mouse   259 SGGPSPAGSPPQPMQSTAGFMNALHSMTPSYDSPSPPAFGKGHQNAYALPSNYQPPLKGCGAPQK 323
                  .||.|..|  ..|..:|.:|......:...|.....|..|:::            .|..
  Fly   352 ------KGSDPNVM--GVGVQHADYSQLLDAKAKLEPGLHLSHSLAHSM------------NPMA 396

Mouse   324 YPPTPASEYEPHV 336
            ....||....||:
  Fly   397 AMNIPAMRLHPHL 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hoxb3	NP_001073338.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	63..124		22/103 (21%)
		Antp-type hexapeptide	129..134		2/4 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	136..195		7/66 (11%)
		Homeobox	195..248	CDD:365835	29/52 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	249..276		5/26 (19%)
		DUF4074	369..431	CDD:372548
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	389..433
cad	NP_001260641.1	Homeobox	295..347	CDD:278475	29/51 (57%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X14
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000