DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hoxb3 and bsh

DIOPT Version :9

Sequence 1:	NP_001073338.1	Gene:	Hoxb3 / 15410	MGIID:	96184	Length:	433	Species:	Mus musculus
Sequence 2:	NP_477350.2	Gene:	bsh / 35266	FlyBaseID:	FBgn0000529	Length:	429	Species:	Drosophila melanogaster

Alignment Length:	307	Identity:	91/307 - (29%)
Similarity:	112/307 - (36%)	Gaps:	87/307 - (28%)

- Green bases have known domain annotations that are detailed below.

Mouse     4 ATYYDNTAAALFGG------YSSYPGSNGFGYDGPPQPPFQAATHLEGDYQRSACSLQSLGNAAP 62
            ||...|.||:.:.|      ..|.|.||.....|        .:|..|| |.|    |.||
  Fly   123 ATARSNQAASGYAGEDYGKSMHSTPRSNHHSRHG--------TSHYNGD-QIS----QQLG---- 170

Mouse    63 HAKSKELNGSCMRPGLAPEPLPAPPGSPPPSAAPTSTTSNSNNGGGPSKSG---PPKCGAGSNST 124
                   :|:...|.: |...|.||  |||..          |||..:.:|   |       |:.
  Fly   171 -------SGAAQHPPV-PTTQPQPP--PPPPL----------NGGSGASNGVLYP-------NAP 208

Mouse   125 LTKQIFPWMK---ESRQTSKLKNSSPGTAEGCGGGGGGGGGGGGGGGGSSGGGGGGGGGGDKSPP 186
            .|...|..|.   .|..:...|:..|.........||....|..|.......|.|.|....:
  Fly   209 YTDHGFLQMTLGYLSPSSGTYKSVDPYFLSQASLFGGAPFFGAPGCVPELALGLGMGVNALR--- 270

Mouse   187 GSAASKRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLSERQIKIWFQNRRMKYKKD-- 249
             ....::|||.::..||..|||.|...|||..|.|||:|..|.|||.|:|.||||||||:||.
  Fly   271 -HCRRRKARTVFSDPQLSGLEKRFEGQRYLSTPERVELATALGLSETQVKTWFQNRRMKHKKQLR 334

Mouse   250 ----------------QKAKGLASSSGGPSP---------AGSPPQP 271
                            .|..|.|:||.|.|.         .|:|.||
  Fly   335 RRDNANEPVDFSRSEPGKQPGEATSSSGDSKHGKLNPGSVGGTPTQP 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hoxb3	NP_001073338.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	63..124		15/63 (24%)
		Antp-type hexapeptide	129..134		1/4 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	136..195		10/58 (17%)
		Homeobox	195..248	CDD:365835	30/52 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	249..276		11/50 (22%)
		DUF4074	369..431	CDD:372548
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	389..433
bsh	NP_477350.2	Homeobox	278..330	CDD:278475	30/51 (59%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910