DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hoxb3 and Lim3

DIOPT Version :9

Sequence 1:	NP_001073338.1	Gene:	Hoxb3 / 15410	MGIID:	96184	Length:	433	Species:	Mus musculus
Sequence 2:	NP_001260559.1	Gene:	Lim3 / 35184	FlyBaseID:	FBgn0002023	Length:	555	Species:	Drosophila melanogaster

Alignment Length:	264	Identity:	58/264 - (21%)
Similarity:	95/264 - (35%)	Gaps:	76/264 - (28%)

- Green bases have known domain annotations that are detailed below.

Mouse   182 DKSPPGSAASKRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLSERQIKIWFQNRRMKY 246
            |.|..|...:||.||..|:.||..|:..::.:....|..|.:::....|..|.:::||||||.|.
  Fly   247 DGSLDGDQPNKRPRTTITAKQLETLKTAYNNSPKPARHVREQLSQDTGLDMRVVQVWFQNRRAKE 311

Mouse   247 KKDQKAKG-------LASSSGGPSPAGSPPQPMQSTAGFMN-----------ALHSMTPSYDSPS 293
            |:.:|..|       ..|..|..||         .|..|::           :.|.:  |.||.|
  Fly   312 KRLKKDAGRTRWSQYFRSMKGNCSP---------RTDKFLDKDELKVDYDSFSHHDL--SNDSYS 365

Mouse   294 PPAFGKGH-QNAYALPSNYQPPLKGCGAPQKYPPTPASEYEPHVLQANGGAYGTPTMQGSPVYVG 357
            ....|... .:.:::..:|   :.|..:|.:|||:..|
  Fly   366 TVNLGLDEGASPHSIRGSY---MHGSSSPSQYPPSSRS--------------------------- 400

Mouse   358 GGGYADPLPPPAGPSLYGLNHLSHHPSG----NLDYNGAAPMGPNQHHGPCDPHPTYTDLSSHHA 418
                    |||.|..    :....:|..    |:|....:.:..::.|.........:|||:..:
  Fly   401 --------PPPVGQG----HTFGSYPDNIVYTNIDQAVGSSLHASKAHHRLHSSNNVSDLSNDSS 453

Mouse   419 PPQG 422
            |.||
  Fly   454 PDQG 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hoxb3	NP_001073338.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	63..124
		Antp-type hexapeptide	129..134
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	136..195		5/12 (42%)
		Homeobox	195..248	CDD:365835	17/52 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	249..276		6/33 (18%)
		DUF4074	369..431	CDD:372548	11/58 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	389..433		7/34 (21%)
Lim3	NP_001260559.1	LIM1_Lhx3_Lhx4	122..173	CDD:188754
		LIM2_Lhx3_Lhx4	181..236	CDD:188762
		Homeobox	259..312	CDD:278475	17/52 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910