DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hoxb3 and unc-4

DIOPT Version :9

Sequence 1:	NP_001073338.1	Gene:	Hoxb3 / 15410	MGIID:	96184	Length:	433	Species:	Mus musculus
Sequence 2:	NP_001285389.1	Gene:	unc-4 / 32757	FlyBaseID:	FBgn0024184	Length:	588	Species:	Drosophila melanogaster

Alignment Length:	417	Identity:	101/417 - (24%)
Similarity:	132/417 - (31%)	Gaps:	118/417 - (28%)

- Green bases have known domain annotations that are detailed below.

Mouse    17 GYSSYPGSNGFGYDGPPQPPFQAATHLEGDYQRSACSLQSLGNAAPH-----AKSKELNGSCMRP 76
            |.||...||..    |......|..||.|....||||....|...|.     ..:.:|..:..:
  Fly    46 GRSSSTSSNSI----PNAHRTNAGQHLLGGSPSSACSTSVSGCGMPSEGLHPTAALQLYAAAAQ- 105

Mouse    77 GLAPEPLPAPPGSP------PPSAAPTSTTSNSNNGGGPSKSGPPKCGA------------GSN- 122
             |||..:..||..|      |....|.............|..|.|...|            .||
  Fly   106 -LAPNGVRVPPWGPFLQFGVPGVFGPNGPFLGRPRFDAASAGGHPNSAAAAAAATQMAAVNASNA 169

Mouse   123 -STLTKQIFPWMKESRQTSKLKNSSPGTAEGCG---------------GGGGGGGGGGGGGGGSS 171
             :.||         ....:.|:|.|........               |........|....||:
  Fly   170 FANLT---------GLSAAALRNVSAAQTTAVAAVASTVATIQHRLMIGNRQSLPPAGPPSEGSN 225

Mouse   172 GGGGGGGGGGDKSPPGSAASKRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLSERQIK 236
            ..||..|.|.|.|  .:|..:|:||.:.|.||.|||:.|..:.|.....|..:|..|:|.|.::.
  Fly   226 EDGGFPGDGDDDS--SAAKRRRSRTNFNSWQLEELERAFSASHYPDIFMREALAMRLDLKESRVA 288

Mouse   237 IWFQNRRMKYKKDQKAKGLASSSGGPSPAGSPPQPMQSTAGFMNALHSMTPSYDSPSPPAFGKGH 301
            :||||||.|.:|.:..|      .||.......|| |:.:|             .|.||...|..
  Fly   289 VWFQNRRAKVRKREHTK------KGPGRPAHNAQP-QTCSG-------------EPIPPNELKAK 333

Mouse   302 QNA--------------------------YALPSNYQPPLKGCGAPQKYPPTPASEYEPHVLQAN 340
            :.|                          .||.:.|....|..|.      ...|:.|...:|.:
  Fly   334 ERARRRKKLAKAIDRQARKLQAKGITVDLEALKAEYISQHKANGT------FSDSDLEDDGIQID 392

Mouse   341 --GGAYGTPTMQG-----SPVYVGGGG 360
              ||.....  :|     |||.:||||
  Fly   393 VVGGTDSDD--EGDSDAVSPVRLGGGG 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hoxb3	NP_001073338.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	63..124		15/85 (18%)
		Antp-type hexapeptide	129..134		0/4 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	136..195		15/73 (21%)
		Homeobox	195..248	CDD:365835	22/52 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	249..276		6/26 (23%)
		DUF4074	369..431	CDD:372548
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	389..433
unc-4	NP_001285389.1	Homeobox	246..299	CDD:278475	22/52 (42%)
unc-4	NP_001285389.1	NK	<327..>368	CDD:302627	5/40 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910