DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hoxb3 and B-H1

DIOPT Version :9

Sequence 1:	NP_001073338.1	Gene:	Hoxb3 / 15410	MGIID:	96184	Length:	433	Species:	Mus musculus
Sequence 2:	NP_523387.1	Gene:	B-H1 / 32724	FlyBaseID:	FBgn0011758	Length:	544	Species:	Drosophila melanogaster

Alignment Length:	450	Identity:	115/450 - (25%)
Similarity:	155/450 - (34%)	Gaps:	143/450 - (31%)

- Green bases have known domain annotations that are detailed below.

Mouse    56 SLGNAAP-HA-KSKELNG-SCMRP-----GLAPEPLPAPPGSPP--PSAAPTSTTSNSNNGGGPS 110
            |.|.::| |: .:..:|| :|...     |:.|..|..|...||  |...|.:..    :..|..
  Fly   112 SSGGSSPAHSNNNNNINGDNCEASNVAGVGVLPSALHHPQPHPPTHPHTHPHALM----HPHGKL 172

Mouse   111 KSGPPKCGAGSNSTLTKQIFPWMKE-----SRQTSKLKNSSPGTAEGCGGGGGG-------GGGG 163
            ...||.  ||.|.....|....|::     :...:...|::...|........|       ||..
  Fly   173 GHFPPT--AGGNGLNVAQYAAAMQQHYAAAAAAAAARNNAAAAAAAAAAAAAAGVAAPPVDGGVD 235

Mouse   164 GGGGGGSSGGG----------------------------GGGGGGGDKSPPGSAA--------SK 192
            ||.|.....||                            ||....|:....||.:        .:
  Fly   236 GGVGLAPPAGGDLDDSSDYHEENEDCDSGNMDDHSVCSNGGKDDDGNSVKSGSTSDMSGLSKKQR 300

Mouse   193 RARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLSERQIKIWFQNRRMKYKKDQKAKG--L 255
            :||||:|..||..|||.|...:||....|.|:|:.|:||:.|:|.|:||||.|:|: |.|.|  |
  Fly   301 KARTAFTDHQLQTLEKSFERQKYLSVQERQELAHKLDLSDCQVKTWYQNRRTKWKR-QTAVGLEL 364

Mouse   256 ASSSGGPSP-----AGSP---PQPMQSTAGFMNALHSMTP---------------SYDSPSPPAF 297
            .:.:|..:.     .|||   ..|..:.||   |.|..||               :...|.|
  Fly   365 LAEAGNFAAFQRLYGGSPYLGAWPYAAAAG---AAHGATPHTNIDIYYRQAAAAAAMQKPLP--- 423

Mouse   298 GKGHQNAYA-LPSNYQPPLKGCGAPQKYPPTP-------------ASEYEPHVLQANGGAYGTPT 348
                .|.|| :||      .|.|......|.|             :|.|:.....|:....|.|.
  Fly   424 ----YNLYAGVPS------VGVGVGVGVGPAPFSHLSASSSLSSLSSYYQSAAAAASAANPGGPH 478

Mouse   349 MQGSPVYVGGG----GYADPL--------PPPAGPSLYGLNHLSHHPSGNLDYNGAAPMG 396
            ....|..||||    |...|:        |||..||.         ||..|  |..:|.|
  Fly   479 PVAPPPSVGGGSPPSGLVKPIPAHSASASPPPRPPST---------PSPTL--NPGSPPG 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hoxb3	NP_001073338.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	63..124		18/69 (26%)
		Antp-type hexapeptide	129..134		0/4 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	136..195		15/101 (15%)
		Homeobox	195..248	CDD:365835	26/52 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	249..276		9/36 (25%)
		DUF4074	369..431	CDD:372548	7/27 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	389..433		2/7 (29%)
B-H1	NP_523387.1	Homeobox	303..355	CDD:278475	26/51 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910