DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hoxb3 and Lim1

DIOPT Version :9

Sequence 1:	NP_001073338.1	Gene:	Hoxb3 / 15410	MGIID:	96184	Length:	433	Species:	Mus musculus
Sequence 2:	NP_572505.1	Gene:	Lim1 / 31813	FlyBaseID:	FBgn0026411	Length:	505	Species:	Drosophila melanogaster

Alignment Length:	411	Identity:	94/411 - (22%)
Similarity:	127/411 - (30%)	Gaps:	132/411 - (32%)

- Green bases have known domain annotations that are detailed below.

Mouse    46 DYQRSACSLQSLGNAAPHAKSKELNGSCMRPGLAPEPLPAPPGSPPPSAAPTSTTSNSNNGGGPS 110
            |..:..|....|...||......|:.|.|  |.|.|.   .....||....|:.........||.
  Fly   131 DDNKFICKDDYLLGKAPSCGHNSLSDSLM--GSASED---DDDDDPPHLRATALGLGVLGPNGPD 190

Mouse   111 KSGPPKCGAGSNSTLTKQIFPWMKESRQTSKLKNSSPGTAEGCGGGGGGGGGGGGGGGGSSGGGG 175
            .:|.|   .|::....:.:   ..:|:.|.  .:|..|:.:|                  ...|.
  Fly   191 SAGGP---LGTSDISVQSM---STDSKNTH--DDSDQGSLDG------------------DPDGR 229

Mouse   176 GGGGGGDKSPPGSAASKR--ARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLSERQIKIW 238
            |.....:|||..:..|||  .||...:.||..|:..|:......|..|.::|....|..|.|::|
  Fly   230 GDSQAENKSPDDANGSKRRGPRTTIKAKQLEVLKTAFNQTPKPTRHIREQLAKETGLPMRVIQVW 294

Mouse   239 FQNRRMKYKKDQKAKGLASSSGGPSPAGSPPQPMQSTAGFMNALHSMTPSYDSPSPPAFGKGHQN 303
            |||:|.|.::                              |..:.||      ..||.|| |.:.
  Fly   295 FQNKRSKERR------------------------------MKQITSM------GRPPFFG-GARK 322

Mouse   304 AYALPSNYQPPLKGCGAPQKYPPTPASEYEPHVLQANGGAYGTPTMQGSPVYVGGG----GYADP 364
            ....|.|..|                           ||....|   |.|.:....    ||..|
  Fly   323 MRGFPMNLSP---------------------------GGLDDGP---GFPYFAADAKFEFGYGGP 357

Mouse   365 LPPPAGPSLYGLNHLSHHPSGNLDYNGAAPMGPNQHHGP--------CDPHPTYTDLSSHHAPPQ 421
            ..|..||...|      ||.|.:.:|  ||.||..|.||        ..|..|:  |.....||.
  Fly   358 FHPHDGPYFPG------HPGGPMPFN--APGGPMDHSGPIPMVNEFGLTPEATF--LGQAGGPPM 412

Mouse   422 GRIQEA---------PKLTHL 433
             ::|.|         |...||
  Fly   413 -QLQSAVGPPPPPPPPSAEHL 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hoxb3	NP_001073338.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	63..124		14/60 (23%)
		Antp-type hexapeptide	129..134		0/4 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	136..195		13/60 (22%)
		Homeobox	195..248	CDD:365835	18/52 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	249..276		0/26 (0%)
		DUF4074	369..431	CDD:372548	22/78 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	389..433		16/60 (27%)
Lim1	NP_572505.1	LIM1_Lhx1_Lhx5	27..78	CDD:188753
		LIM2_Lhx1_Lhx5	86..141	CDD:188761	2/9 (22%)
		COG5576	185..324	CDD:227863	44/201 (22%)
		Homeobox	250..303	CDD:278475	18/52 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910