DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hoxa3 and ftz

DIOPT Version :9

Sequence 1:	NP_034582.1	Gene:	Hoxa3 / 15400	MGIID:	96175	Length:	443	Species:	Mus musculus
Sequence 2:	NP_477498.1	Gene:	ftz / 40834	FlyBaseID:	FBgn0001077	Length:	410	Species:	Drosophila melanogaster

Alignment Length:	414	Identity:	121/414 - (29%)
Similarity:	155/414 - (37%)	Gaps:	132/414 - (31%)

- Green bases have known domain annotations that are detailed below.

Mouse     5 TYYD---SSAIY-------GGYPYQAANGFAY---NASQ---------QPYAP-----------S 36
            ||||   |:|.|       |.||.::.:...|   |..|         ||..|           .
  Fly    30 TYYDNSGSNAYYQNTSNYQGYYPQESYSESCYYYNNQEQVTTQTVPPVQPTTPPPKATKRKAEDD 94

Mouse    37 AALGTDGVEYHRPA---CSLQSPASAGGHPKTH------ELSEACLRTLSGPPSQPPGLGEPPLP 92
            ||.....|| .||:   ..|.:|.....:...:      ::.:|...:.....|..|...:..:.
  Fly    95 AASIIAAVE-ERPSTLRALLTNPVKKLKYTPDYFYTTVEQVKKAPAVSTKVTASPAPSYDQEYVT 158

Mouse    93 PPPPQAAPPAP----QPPQPPPQ---------PPAPTPAAPPPPSSVS-PPQSANSNPTPASTAK 143
            .|.|.|:....    ..||...|         ||..||.:.||...:| ||||....   :|:|.
  Fly   159 VPTPSASEDVDYLDVYSPQSQTQKLKNGDFATPPPTTPTSLPPLEGISTPPQSPGEK---SSSAV 220

Mouse   144 SPLLNSPTV----GKQIFPWMKESRQNTKQKTSGSSSGESCAGDKSPPGQASSKRARTAYTSAQL 204
            |..:|...|    |...|.|              |...|:.|.|..     .|||.|..||..|.
  Fly   221 SQEINHRIVTAPNGAGDFNW--------------SHIEETLASDCK-----DSKRTRQTYTRYQT 266

Mouse   205 VELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYKKDQKGKGMLTSSGGQSPSRSP 269
            :|||||||||||:.|.||:::||.|:|:||||||||||||||.|||            ::...||
  Fly   267 LELEKEFHFNRYITRRRRIDIANALSLSERQIKIWFQNRRMKSKKD------------RTLDSSP 319

Mouse   270 VPPGAGGYLNSMHSLVNSVPYEPQSPPPFSKPPQGAYGLPPASYPAPLPSCAPPPPPQKRYTAAG 334
            ...|| ||...:              ||.........|.|  |.|.|:..       ..:.|||
  Fly   320 EHCGA-GYTAML--------------PPLEATSTATTGAP--SVPVPMYH-------HHQTTAA- 359

Mouse   335 SGAGGTPDYD-PHAHGLQGNGSYG 357
                 .|.|. .|:||      ||
  Fly   360 -----YPAYSHSHSHG------YG 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hoxa3	NP_034582.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	74..151		23/90 (26%)
		Antp-type hexapeptide	156..161		2/4 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	163..197		7/33 (21%)
		COG5576	<182..309	CDD:227863	52/126 (41%)
		Homeobox	196..249	CDD:365835	36/52 (69%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	248..354		24/106 (23%)
		DUF4074	378..441	CDD:372548
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	401..443
ftz	NP_477498.1	FTZ	1..248	CDD:281812	54/235 (23%)
ftz	NP_477498.1	Homeobox	257..310	CDD:278475	36/52 (69%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	107	1.000	Inparanoid score	I4905
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.860