DRSC/TRiP Functional Genomics Resources

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Protein Alignment ADRB2 and Dop1R2

DIOPT Version :10

Sequence 1:NP_000015.2 Gene:ADRB2 / 154 HGNCID:286 Length:413 Species:Homo sapiens
Sequence 2:NP_001263072.1 Gene:Dop1R2 / 43484 FlyBaseID:FBgn0266137 Length:807 Species:Drosophila melanogaster


Alignment Length:505 Identity:164/505 - (32%)
Similarity:222/505 - (43%) Gaps:127/505 - (25%)


- Green bases have known domain annotations that are detailed below.


Human    16 GSHAPDHDVTQ-----ERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSL 75
            |:..|:.|:::     ..|.   ||:...:.|...|.||||.|||.|:.:...|.|.||||||||
  Fly    89 GTTTPEPDLSEFLEALPNDR---VGLLAFLFLFSFATVFGNSLVILAVIRERYLHTATNYFITSL 150

Human    76 ACADLVMGLAVVPFGAAH-ILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPF 139
            |.||.::||.|:||.|.: :|...|.||..||:.|.|:|||..||||..||||::|||:|||.||
  Fly   151 AVADCLVGLVVMPFSALYEVLENTWFFGTDWCDIWRSLDVLFSTASILNLCVISLDRYWAITDPF 215

Human   140 KYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASS 204
            .|...:|..:|..:|..|||.|...||..|.  |:||.....:..|.    |.|..:..|.:.||
  Fly   216 SYPMRMTVKRAAGLIAAVWICSSAISFPAIV--WWRAARDGEMPAYK----CTFTEHLGYLVFSS 274

Human   205 IVSFYVPLVIMVFVYSRVFQEAKRQLQKI------------------------------------ 233
            .:|||:||::|||.|.|:::.|..|.:.:                                    
  Fly   275 TISFYLPLLVMVFTYCRIYRAAVIQTRSLKIGTKQVLMASGELQLTLRIHRGGTTRDQQNQVSGG 339

Human   234 ----------------DKSEGRFHVQN-----------------LSQVEQDGRTGHG-------- 257
                            ..|....|..|                 ||.:..:|...|.        
  Fly   340 GGGGGGGGGGGGSLSHSHSHSHHHHHNHGGGTTTSTPEEPDDEPLSALHNNGLARHRHMGKNFSL 404

Human   258 LRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKE--VYILLNWIGYVNSG 320
            .|:.:||. ||.||.|||||:||.|.:||||||:||::.......|..|  |..::.|:|::||.
  Fly   405 SRKLAKFA-KEKKAAKTLGIVMGVFIICWLPFFVVNLLSGFCIECIEHEEIVSAIVTWLGWINSC 468

Human   321 FNPLIY-CRSPDFRIAFQELLCL--RRSSLKAYGNGYSSNGN---------TGEQSGYHVEQEKE 373
            .||:|| |.|.|||.||..|||:  .|...:.|.....|...         .....|||...:.:
  Fly   469 MNPVIYACWSRDFRRAFVRLLCMCCPRKIRRKYQPTMRSKSQCHVAAAMVAASTSFGYHSVNQID 533

Human   374 NKLL------CEDLPGTEDFVG-----HQ----GT-VPSDNIDSQGRNCS 407
            ..|:      |....|..:..|     ||    || .||    |..|:|:
  Fly   534 RTLMXRQLSSCSTCSGGSNCGGSRSAHHQHHSSGTATPS----SSQRSCT 579

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ADRB2NP_000015.2 7tmA_Beta2_AR 34..336 CDD:341355 136/382 (36%)
TM helix 1 35..61 CDD:341355 11/25 (44%)
TM helix 2 68..95 CDD:341355 17/27 (63%)
TM helix 3 106..136 CDD:341355 18/29 (62%)
TM helix 4 148..171 CDD:341355 9/22 (41%)
TM helix 5 196..228 CDD:341355 14/31 (45%)
TM helix 6 266..296 CDD:341355 20/29 (69%)
TM helix 7 305..330 CDD:341355 11/27 (41%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 392..413 7/17 (41%)
PDZ-binding 410..413
Dop1R2NP_001263072.1 7tmA_Dop1R2-like 122..485 CDD:320195 132/369 (36%)
TM helix 2 143..169 CDD:320195 17/25 (68%)
TM helix 3 182..212 CDD:320195 18/29 (62%)
TM helix 4 224..246 CDD:320195 8/21 (38%)
TM helix 5 266..295 CDD:320195 13/28 (46%)
TM helix 6 297..442 CDD:320195 31/145 (21%)
TM helix 7 453..478 CDD:320195 10/24 (42%)
Blue background indicates that the domain is not in the aligned region.

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