DRSC/TRiP Functional Genomics Resources

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Protein Alignment ADRB2 and Oct-TyrR

DIOPT Version :10

Sequence 1:NP_000015.2 Gene:ADRB2 / 154 HGNCID:286 Length:413 Species:Homo sapiens
Sequence 2:NP_524419.2 Gene:Oct-TyrR / 42452 FlyBaseID:FBgn0004514 Length:601 Species:Drosophila melanogaster


Alignment Length:497 Identity:122/497 - (24%)
Similarity:182/497 - (36%) Gaps:202/497 - (40%)


- Green bases have known domain annotations that are detailed below.


Human    38 IVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFG 102
            :|:|:|::..:.||:|||.::..::.|:.|.|:||.|||.|||.:.|.|:||..|:.::..|.||
  Fly   114 LVLSVIIVLTIIGNILVILSVFTYKPLRIVQNFFIVSLAVADLTVALLVLPFNVAYSILGRWEFG 178

Human   103 NFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFL 167
            ...|:.|.:.||||.|:||..||.||:|||:|||.|..|....|..:..::|..||::|.|.|..
  Fly   179 IHLCKLWLTCDVLCCTSSILNLCAIALDRYWAITDPINYAQKRTVGRVLLLISGVWLLSLLISSP 243

Human   168 PIQMHWYRATHQEAINCYANE----TCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKR 228
            |: :.|         |.:.:|    |.|:..:.:.|.|.||:.||::||.||..||..:|...:|
  Fly   244 PL-IGW---------NDWPDEFTSATPCELTSQRGYVIYSSLGSFFIPLAIMTIVYIEIFVATRR 298

Human   229 QLQ-------------------------------------------------------------- 231
            :|:                                                              
  Fly   299 RLRERARANKLNTIALKSTELEPMANSSPVAASNSGSKSRLLASWLCCGRDRAQFATPMIQNDQE 363

Human   232 --------------------------------------------KIDKSEGRFHVQNLSQVEQDG 252
                                                        |..|:.|....|:.|..|..|
  Fly   364 SISSETHQPQDSSKAGPHGNSDPQQQHVVVLVKKSRRAKTKDSIKHGKTRGGRKSQSSSTCEPHG 428

Human   253 RT----------------GHG-------------------------------------------- 257
            ..                ||.                                            
  Fly   429 EQQLLPAGGDGGSCQPGGGHSGGGKSDAEISTESGSDPKGCIQVCVTQADEQTSLKLTPPQSSTG 493

Human   258 -------------------LRRSSKFCL-KEHKALKTLGIIMGTFTLCWLPFFIVNIV-HVIQDN 301
                               :....|..| ||.:|.:|||||||.|.:||||||::.:: ...|..
  Fly   494 VAAVSVTPLQKKTSGVNQFIEEKQKISLSKERRAARTLGIIMGVFVICWLPFFLMYVILPFCQTC 558

Human   302 LIRKEVYILLNWIGYVNSGFNPLIY-CRSPDFRIAFQELLCL 342
            ....:....:.|:||:|||.||:|| ..:.|:|.||:.||.|
  Fly   559 CPTNKFKNFITWLGYINSGLNPVIYTIFNLDYRRAFKRLLGL 600

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ADRB2NP_000015.2 7tmA_Beta2_AR 34..336 CDD:341355 117/489 (24%)
TM helix 1 35..61 CDD:341355 8/22 (36%)
TM helix 2 68..95 CDD:341355 14/26 (54%)
TM helix 3 106..136 CDD:341355 17/29 (59%)
TM helix 4 148..171 CDD:341355 7/22 (32%)
TM helix 5 196..228 CDD:341355 13/31 (42%)
TM helix 6 266..296 CDD:341355 18/31 (58%)
TM helix 7 305..330 CDD:341355 10/25 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 392..413
PDZ-binding 410..413
Oct-TyrRNP_524419.2 7tmA_tyramine_octopamine_R-like 110..>294 CDD:320188 73/189 (39%)
TM helix 1 111..137 CDD:320188 8/22 (36%)
TM helix 2 144..170 CDD:320188 14/25 (56%)
TM helix 3 182..212 CDD:320188 17/29 (59%)
TM helix 4 224..247 CDD:320188 7/23 (30%)
TM helix 5 266..294 CDD:320188 12/27 (44%)
7tm_GPCRs <519..594 CDD:475119 31/74 (42%)
TM helix 6 528..550 CDD:410628 14/21 (67%)
TM helix 7 562..587 CDD:410628 10/24 (42%)
Blue background indicates that the domain is not in the aligned region.

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