DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ADRB2 and Dop1R1

DIOPT Version :9

Sequence 1:	NP_000015.2	Gene:	ADRB2 / 154	HGNCID:	286	Length:	413	Species:	Homo sapiens
Sequence 2:	NP_001262563.1	Gene:	Dop1R1 / 41726	FlyBaseID:	FBgn0011582	Length:	560	Species:	Drosophila melanogaster

Alignment Length:	426	Identity:	132/426 - (30%)
Similarity:	208/426 - (48%)	Gaps:	67/426 - (15%)

- Green bases have known domain annotations that are detailed below.

Human     8 SAFLLAPNGSHAPDHD-VTQERDE----VWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTV 67
            ::|....:.::|.:.| :..|..|    |.:|.:||.:|:::...|.||:||..||.....|:.:
  Fly    98 TSFYNESSWTNASEMDTIVGEEPEPLSLVSIVVVGIFLSVLIFLSVAGNILVCLAIYTERSLRRI 162

Human    68 TNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRY 132
            .|.|:.|||.|||.:...|:.|...:.|:..|.||..:|:.|.:.||:|.||||..||.|::|||
  Fly   163 GNLFLASLAIADLFVASLVMTFAGVNDLLGYWIFGAQFCDTWVAFDVMCSTASILNLCAISMDRY 227

Human   133 FAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAI---NCYANETCCDFF 194
            ..|..|.:|...:|:..|.:.|..:|:::...||:||.:..:| ..|..|   |.....||....
  Fly   228 IHIKDPLRYGRWVTRRVAVITIAAIWLLAAFVSFVPISLGIHR-PDQPLIFEDNGKKYPTCALDL 291

Human   195 TNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGH--- 256
            | ..||:.||.:|||.|.|:|:.:|.|::..|::            ||:::..|.:.|....
  Fly   292 T-PTYAVVSSCISFYFPCVVMIGIYCRLYCYAQK------------HVKSIKAVTRPGEVAEKQR 343

Human   257 --GLRR----------------SSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLI 303
              .:||                ||.:.:.:|||..|:|:|||.|.:||:|||.|||........|
  Fly   344 YKSIRRPKNQPKKFKVRNLHTHSSPYHVSDHKAAVTVGVIMGVFLICWVPFFCVNITAAFCKTCI 408

Human   304 RKEVYILLNWIGYVNSGFNPLIY-CRSPDFRIAFQELLCLRR--SSLKAYGNGYSSNG------- 358
            ..:.:.:|.|:||.||.|||:|| ..:.:||.||:.:|.:|.  ...:..||.:..|.
  Fly   409 GGQTFKILTWLGYSNSAFNPIIYSIFNKEFRDAFKRILTMRNPWCCAQDVGNIHPRNSDRFITDY 473

Human   359 --------NTGEQSGYHVEQEKENKL---LCEDLPG 383
                    |:|..|   .|.|:.:.:   .|.:|.|
  Fly   474 AAKNVVVMNSGRSS---AELEQVSAIXPKCCLNLTG 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ADRB2	NP_000015.2	7tmA_Beta2_AR	34..336	CDD:341355	111/326 (34%)
		TM helix 1	36..60	CDD:341355	10/23 (43%)
		TM helix 2	69..91	CDD:341355	10/21 (48%)
		TM helix 3	107..129	CDD:341355	11/21 (52%)
		TM helix 4	152..168	CDD:341355	4/15 (27%)
		TM helix 5	197..220	CDD:341355	10/22 (45%)
		TM helix 6	272..294	CDD:341355	12/21 (57%)
		TM helix 7	305..330	CDD:341355	11/25 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	392..413
		PDZ-binding	410..413
Dop1R1	NP_001262563.1	7tm_4	134..>266	CDD:304433	49/131 (37%)
Dop1R1	NP_001262563.1	7tm_1	145..431	CDD:278431	102/299 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910