Protein Alignment ADRB2 and Dop1R1

DIOPT Version :10

• Sequence 1: NP_000015.2
• Gene: ADRB2 / 154
• HGNCID: 286
• Length: 413
• Species: Homo sapiens
• Sequence 2: NP_001262563.1
• Gene: Dop1R1 / 41726
• FlyBaseID: FBgn0011582
• Length: 560
• Species: Drosophila melanogaster
• Alignment Length: 426
• Identity: 132/426 - (30%)
• Similarity: 208/426 - (48%)
• Gaps: 67/426 - (15%)

Human     8 SAFLLAPNGSHAPDHD-VTQERDE----VWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTV 67
            ::|....:.::|.:.| :..|..|    |.:|.:||.:|:::...|.||:||..||.....|:.:
  Fly    98 TSFYNESSWTNASEMDTIVGEEPEPLSLVSIVVVGIFLSVLIFLSVAGNILVCLAIYTERSLRRI 162

Human    68 TNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRY 132
            .|.|:.|||.|||.:...|:.|...:.|:..|.||..:|:.|.:.||:|.||||..||.|::|||
  Fly   163 GNLFLASLAIADLFVASLVMTFAGVNDLLGYWIFGAQFCDTWVAFDVMCSTASILNLCAISMDRY 227

Human   133 FAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAI---NCYANETCCDFF 194
            ..|..|.:|...:|:..|.:.|..:|:::...||:||.:..:| ..|..|   |.....||....
  Fly   228 IHIKDPLRYGRWVTRRVAVITIAAIWLLAAFVSFVPISLGIHR-PDQPLIFEDNGKKYPTCALDL 291

Human   195 TNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGH--- 256
            | ..||:.||.:|||.|.|:|:.:|.|::..|::            ||:::..|.:.|....
  Fly   292 T-PTYAVVSSCISFYFPCVVMIGIYCRLYCYAQK------------HVKSIKAVTRPGEVAEKQR 343

Human   257 --GLRR----------------SSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLI 303
              .:||                ||.:.:.:|||..|:|:|||.|.:||:|||.|||........|
  Fly   344 YKSIRRPKNQPKKFKVRNLHTHSSPYHVSDHKAAVTVGVIMGVFLICWVPFFCVNITAAFCKTCI 408

Human   304 RKEVYILLNWIGYVNSGFNPLIY-CRSPDFRIAFQELLCLRR--SSLKAYGNGYSSNG------- 358
            ..:.:.:|.|:||.||.|||:|| ..:.:||.||:.:|.:|.  ...:..||.:..|.
  Fly   409 GGQTFKILTWLGYSNSAFNPIIYSIFNKEFRDAFKRILTMRNPWCCAQDVGNIHPRNSDRFITDY 473

Human   359 --------NTGEQSGYHVEQEKENKL---LCEDLPG 383
                    |:|..|   .|.|:.:.:   .|.:|.|
  Fly   474 AAKNVVVMNSGRSS---AELEQVSAIXPKCCLNLTG 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ADRB2	NP_000015.2	7tmA_Beta2_AR	34..336	CDD:341355	111/326 (34%)
		TM helix 1	35..61	CDD:341355	10/25 (40%)
		TM helix 2	68..95	CDD:341355	10/26 (38%)
		TM helix 3	106..136	CDD:341355	15/29 (52%)
		TM helix 4	148..171	CDD:341355	7/22 (32%)
		TM helix 5	196..228	CDD:341355	13/31 (42%)
		TM helix 6	266..296	CDD:341355	17/29 (59%)
		TM helix 7	305..330	CDD:341355	11/25 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	392..413
		PDZ-binding	410..413
Dop1R1	NP_001262563.1	7tmA_Ap5-HTB1-like	130..442	CDD:320193	110/325 (34%)
		TM helix 1	130..156	CDD:320193	10/25 (40%)
		TM helix 2	163..189	CDD:320193	10/25 (40%)
		TM helix 3	201..231	CDD:320193	15/29 (52%)
		TM helix 4	243..265	CDD:320193	6/21 (29%)
		TM helix 5	292..321	CDD:320193	13/29 (45%)
		TM helix 6	371..401	CDD:320193	17/29 (59%)
		TM helix 7	410..435	CDD:320193	11/24 (46%)