DRSC/TRiP Functional Genomics Resources

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Protein Alignment ADRB2 and Octbeta2R

DIOPT Version :10

Sequence 1:NP_000015.2 Gene:ADRB2 / 154 HGNCID:286 Length:413 Species:Homo sapiens
Sequence 2:NP_001163596.2 Gene:Octbeta2R / 41549 FlyBaseID:FBgn0038063 Length:630 Species:Drosophila melanogaster


Alignment Length:405 Identity:147/405 - (36%)
Similarity:206/405 - (50%) Gaps:55/405 - (13%)


- Green bases have known domain annotations that are detailed below.


Human     3 QPGNGSAFLLAPNGSHAPDHDVTQER--DEVWV-----VGMGIVMSLIVLAIVFGNVLVITAIAK 60
            ||..||......:|:...||...|:.  ||.|:     |....||.||::|.:.||:|||.::.:
  Fly   116 QPFGGSGLNFNESGAGLSDHHHHQQHNPDEDWLDNIVWVFKAFVMLLIIIAAICGNLLVIISVMR 180

Human    61 FERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLC 125
            ..:|:.:||||:.|||.||:::.:..:.|..:..:...|.|..|.|:.|.|:||...||||..||
  Fly   181 VRKLRVITNYFVVSLAMADIMVAIMAMTFNFSVQVTGRWNFSPFLCDLWNSLDVYFSTASILHLC 245

Human   126 VIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRA-THQEAINCYANET 189
            .|:||||:||..|.||...:||....:::|..||...|.|||||.:.||.. .||:.:  ..|.|
  Fly   246 CISVDRYYAIVKPLKYPISMTKRVVGIMLLNTWISPALLSFLPIFIGWYTTPQHQQFV--IQNPT 308

Human   190 CCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRT 254
            .|.|..|:.||:.||.:||::|..||:|.|..:|:||.||.:::....|...:.:...::..|..
  Fly   309 QCSFVVNKYYAVISSSISFWIPCTIMIFTYLAIFREANRQEKQLMMRHGNAMLMHRPSMQPSGEA 373

Human   255 GHGLRRSSKFCL-------------------KEHKALKTLGIIMGTFTLCWLPFFI-VNIVHVIQ 299
            ..|...|....|                   :||||.:|||||||||.|||||||: ..:....:
  Fly   374 LSGSGSSKTLTLHEVEQEHTPTKDKHLIKMKREHKAARTLGIIMGTFILCWLPFFLWYTLSMTCE 438

Human   300 DNLIRKEVYILLNWIGYVNSGFNPLIYCR-SPDFRIAFQE-LLCL----------------RRSS 346
            :..:...|..:|.||||.||..|||||.. :.|||.||:. ||||                ||||
  Fly   439 ECQVPDIVVSILFWIGYFNSTLNPLIYAYFNRDFREAFRNTLLCLFCNWWKDRHLPLDIDIRRSS 503

Human   347 LK-------AYGNGY 354
            |:       .|...|
  Fly   504 LRYDQRAKSVYSESY 518

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ADRB2NP_000015.2 7tmA_Beta2_AR 34..336 CDD:341355 123/323 (38%)
TM helix 1 35..61 CDD:341355 10/25 (40%)
TM helix 2 68..95 CDD:341355 10/26 (38%)
TM helix 3 106..136 CDD:341355 17/29 (59%)
TM helix 4 148..171 CDD:341355 9/22 (41%)
TM helix 5 196..228 CDD:341355 15/31 (48%)
TM helix 6 266..296 CDD:341355 21/49 (43%)
TM helix 7 305..330 CDD:341355 13/25 (52%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 392..413
PDZ-binding 410..413
Octbeta2RNP_001163596.2 7tmA_DmOct-betaAR-like 155..476 CDD:320194 122/322 (38%)
TM helix 1 155..181 CDD:320194 10/25 (40%)
TM helix 2 188..214 CDD:320194 10/25 (40%)
TM helix 3 226..256 CDD:320194 17/29 (59%)
TM helix 4 268..291 CDD:320194 9/22 (41%)
TM helix 5 315..344 CDD:320194 13/28 (46%)
TM helix 6 404..434 CDD:320194 20/29 (69%)
TM helix 7 444..469 CDD:320194 13/24 (54%)
Blue background indicates that the domain is not in the aligned region.

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