DRSC/TRiP Functional Genomics Resources

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Protein Alignment ADRB2 and 5-HT2B

DIOPT Version :10

Sequence 1:NP_000015.2 Gene:ADRB2 / 154 HGNCID:286 Length:413 Species:Homo sapiens
Sequence 2:NP_001262373.1 Gene:5-HT2B / 41017 FlyBaseID:FBgn0261929 Length:947 Species:Drosophila melanogaster


Alignment Length:211 Identity:71/211 - (33%)
Similarity:110/211 - (52%) Gaps:11/211 - (5%)


- Green bases have known domain annotations that are detailed below.


Human    23 DVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVV 87
            ||..:.:..|    .::..::||....||:||..|||...|||.|||||:.|||..||::.:.|:
  Fly    67 DVPFDANNYW----ALLALVLVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVM 127

Human    88 PFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARV 152
            |.|...::...:..|:..|..|..:|||..||||..||.|:||||.::..|.::....|:.:..:
  Fly   128 PLGILTLVKGYFPLGSEHCLTWICLDVLFCTASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTL 192

Human   153 IILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVF 217
            .|:.||::| :...||:.: .|...|...:   .|.||  ...:..|.:..|||.||:||.:|:.
  Fly   193 KIVFVWLLS-IAMSLPLSL-MYSKNHASVL---VNGTC--QIPDPVYKLVGSIVCFYIPLGVMLL 250

Human   218 VYSRVFQEAKRQLQKI 233
            .|....:...||.|.:
  Fly   251 TYCLTVRLLARQRQNL 266

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ADRB2NP_000015.2 7tmA_Beta2_AR 34..336 CDD:341355 68/200 (34%)
TM helix 1 35..61 CDD:341355 9/25 (36%)
TM helix 2 68..95 CDD:341355 12/26 (46%)
TM helix 3 106..136 CDD:341355 16/29 (55%)
TM helix 4 148..171 CDD:341355 6/22 (27%)
TM helix 5 196..228 CDD:341355 10/31 (32%)
TM helix 6 266..296 CDD:341355
TM helix 7 305..330 CDD:341355
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 392..413
PDZ-binding 410..413
5-HT2BNP_001262373.1 7tmA_5-HT2_insect-like 74..>267 CDD:320433 69/204 (34%)
TM helix 1 75..101 CDD:320433 10/29 (34%)
TM helix 2 108..134 CDD:320433 12/25 (48%)
TM helix 3 146..176 CDD:320433 16/29 (55%)
TM helix 4 188..211 CDD:320433 6/24 (25%)
TM helix 5 229..258 CDD:320433 10/28 (36%)
7tm_GPCRs <799..893 CDD:475119
TM helix 6 818..840 CDD:410628
TM helix 7 854..879 CDD:410628
Blue background indicates that the domain is not in the aligned region.

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