DRSC/TRiP Functional Genomics Resources

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Protein Alignment ADRB2 and 5-HT2A

DIOPT Version :10

Sequence 1:NP_000015.2 Gene:ADRB2 / 154 HGNCID:286 Length:413 Species:Homo sapiens
Sequence 2:NP_730859.1 Gene:5-HT2A / 40575 FlyBaseID:FBgn0087012 Length:930 Species:Drosophila melanogaster


Alignment Length:608 Identity:118/608 - (19%)
Similarity:172/608 - (28%) Gaps:335/608 - (55%)


- Green bases have known domain annotations that are detailed below.


Human    42 LIVLAIVF----GNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFG 102
            |.|:..:|    ||:||..|:|...:||.|||||:.|||.|||::.|.|:|.||....:..|..|
  Fly   290 LFVVFFIFAGGLGNILVCLAVALDRKLQNVTNYFLFSLAIADLLVSLFVMPMGAIPAFLGYWPLG 354

Human   103 NFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTS-- 165
            ..||..:.:.|||..::||..:|.|::.||..|.:|...:...||....:.|.:||:::.:.|  
  Fly   355 FTWCNIYVTCDVLACSSSILHMCFISLGRYMGIRNPLGSRHRSTKRLTGIKIAIVWVMAMMVSSS 419

Human   166 -----------FLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVY 219
                       .:|           |...|..|        |:|:.:..|:|:||:|:::||..|
  Fly   420 ITVLGLVNEKNIMP-----------EPNICVIN--------NRAFFVFGSLVAFYIPMLMMVTTY 465

Human   220 -------------------SRVF-----------QEAKRQLQK-----------IDKSEGRFHVQ 243
                               |.:|           |.:::|||.           :...:|..:..
  Fly   466 ALTIPLLRKKARFAAEHPESELFRRLGGRFTLRPQHSQQQLQMFSSFSGSNNKFLSMGDGNRNFN 530

Human   244 NLSQVEQDG------------------RT----------------------GHGLR--------- 259
            ...::|:.|                  ||                      |.|.|         
  Fly   531 TEGEMEEGGAPSRRSGVEPAERPLMQQRTASSRSMGTVSFRNVVNGTSGAAGSGRRTTGTAHSSF 595

Human   260 -------------------------RSSKFCLK-------------------------------- 267
                                     |||.|..|                                
  Fly   596 RFSGAGIFRHSSSSPASSCHSTSTSRSSSFWRKHGGYPNLMDRLAIHLRLSLVPPSSHPNRRASV 660

Human   268 ----------------------------------------------------------------- 267
                                                                             
  Fly   661 RVTISQPQLGYPTNVGGNGGRTVGATEVGAGGNGSSAGRTSNSSLGGTSLMKIATIQGPILNQSQ 725

Human   268 --------------------------------------------------------------EHK 270
                                                                          |.|
  Fly   726 AAGGNHMVQKVKPTALKPEEPQRNKVRPFKFAFNRVATPTLNLRFLNNRSKRNSLSANAVATEQK 790

Human   271 ALKTLGIIMGTFTLCWLPFFIVNIV-----------HVIQDNLIRKEVYILLNWIGYVNSGFNPL 324
            |.|.||::..||.|||.||||:||:           ||:...|          |:|||:|..||:
  Fly   791 ATKVLGLVFFTFVLCWSPFFILNIIFAACPECQVPEHVVNTCL----------WLGYVSSTINPI 845

Human   325 IY-CRSPDFRIAFQELL---CLR 343
            || ..:..||.||..||   |.|
  Fly   846 IYTIFNRTFRAAFIRLLKCNCKR 868

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ADRB2NP_000015.2 7tmA_Beta2_AR 34..336 CDD:341355 112/596 (19%)
TM helix 1 35..61 CDD:341355 9/22 (41%)
TM helix 2 68..95 CDD:341355 15/26 (58%)
TM helix 3 106..136 CDD:341355 10/29 (34%)
TM helix 4 148..171 CDD:341355 5/35 (14%)
TM helix 5 196..228 CDD:341355 13/61 (21%)
TM helix 6 266..296 CDD:341355 18/199 (9%)
TM helix 7 305..330 CDD:341355 9/25 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 392..413
PDZ-binding 410..413
5-HT2ANP_730859.1 7tm_GPCRs 298..>473 CDD:475119 59/193 (31%)
TM helix 2 321..343 CDD:410628 12/21 (57%)
TM helix 3 359..381 CDD:410628 7/21 (33%)
TM helix 4 404..420 CDD:410628 4/15 (27%)
TM helix 5 443..466 CDD:410628 8/22 (36%)
7tm_GPCRs <779..858 CDD:475119 31/88 (35%)
TM helix 6 792..814 CDD:410628 12/21 (57%)
TM helix 7 826..851 CDD:410628 12/34 (35%)
Blue background indicates that the domain is not in the aligned region.

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