DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ADRB2 and Octbeta3R

DIOPT Version :9

Sequence 1:	NP_000015.2	Gene:	ADRB2 / 154	HGNCID:	286	Length:	413	Species:	Homo sapiens
Sequence 2:	NP_001034048.2	Gene:	Octbeta3R / 3885573	FlyBaseID:	FBgn0250910	Length:	1256	Species:	Drosophila melanogaster

Alignment Length:	286	Identity:	96/286 - (33%)
Similarity:	150/286 - (52%)	Gaps:	33/286 - (11%)

- Green bases have known domain annotations that are detailed below.

Human    12 LAPNGSH-APDHDVTQERDEVW-----VVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNY 70
            :..|||. |.|:..  |.:|.|     ::..|.:.|.|:||.|.||.|||.::.:..:|:.:|||
  Fly   114 ITANGSDIAVDNQA--ELEESWLDLSLLLLKGFIFSSIILAAVLGNALVIISVQRNRKLRVITNY 176

Human    71 FITSLACADLVMGLAVVPFGAA-HILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFA 134
            |:.|||.||:::.|..:.|.|: .:....|.||.|.|..:.|:||...||||..||.|:||||:|
  Fly   177 FVVSLAMADMLVALCAMTFNASVELSGGKWMFGPFMCNVYNSLDVYFSTASILHLCCISVDRYYA 241

Human   135 ITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRA-THQEAINCYANETCCDFFTNQA 198
            |..|.:|...:|......::..|||:..|.||.||.:.||.. .|...|:.:.::  |.|..|:|
  Fly   242 IVRPLEYPLNMTHKTVCFMLANVWILPALISFTPIFLGWYTTEEHLREISLHPDQ--CSFVVNKA 304

Human   199 YAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSK 263
            ||:.||.|||::|.::|:.:|.|:|:||.||.:.:.::.....:.::       ..||..:.:|.
  Fly   305 YALISSSVSFWIPGIVMLVMYWRIFKEAIRQRKALSRTSSNILLNSV-------HMGHTQQPTSL 362

Human   264 FCL--------------KEHKALKTL 275
            ..|              :.|.||..|
  Fly   363 SYLHPSDCDLNATSAREETHSALSNL 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ADRB2	NP_000015.2	7tmA_Beta2_AR	34..336	CDD:341355	88/258 (34%)
		TM helix 1	36..60	CDD:341355	11/23 (48%)
		TM helix 2	69..91	CDD:341355	10/21 (48%)
		TM helix 3	107..129	CDD:341355	10/21 (48%)
		TM helix 4	152..168	CDD:341355	6/15 (40%)
		TM helix 5	197..220	CDD:341355	10/22 (45%)
		TM helix 6	272..294	CDD:341355	2/4 (50%)
		TM helix 7	305..330	CDD:341355
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	392..413
		PDZ-binding	410..413
Octbeta3R	NP_001034048.2	7tm_4	146..>346	CDD:304433	79/201 (39%)
Octbeta3R	NP_001034048.2	7tm_1	156..>344	CDD:278431	74/189 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	230	1.000	Domainoid score	I2451
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40768
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24248
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	4.010