DRSC/TRiP Functional Genomics Resources

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Protein Alignment ADRB2 and 5-HT1A

DIOPT Version :10

Sequence 1:NP_000015.2 Gene:ADRB2 / 154 HGNCID:286 Length:413 Species:Homo sapiens
Sequence 2:NP_001356890.1 Gene:5-HT1A / 37196 FlyBaseID:FBgn0004168 Length:846 Species:Drosophila melanogaster


Alignment Length:631 Identity:125/631 - (19%)
Similarity:191/631 - (30%) Gaps:309/631 - (48%)


- Green bases have known domain annotations that are detailed below.


Human     6 NGSAFLLAPNGSHAPDHDVTQERDEVWVVGM---GIVMSLIVLAIVFGNVLVITAIAKFERLQTV 67
            ||:..|.......|.| |.||      ::.|   .:::.|::|..:.|||.||.||.....||.|
  Fly   203 NGTGGLNVTTSKVAED-DFTQ------LLRMAVTSVLLGLMILVTIIGNVFVIAAIILERNLQNV 260

Human    68 TNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRY 132
            .||.:.|||.|||.:...|:|.||.:.:.:.|..|...|:.|||.||||.||||..|..||||||
  Fly   261 ANYLVASLAVADLFVACLVMPLGAVYEISQGWILGPELCDIWTSCDVLCCTASILHLVAIAVDRY 325

Human   133 FAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQ 197
            :|:|: ..|....|.|:..::|..||..:.:.|..| |..|....:.:.|    .:..|....:.
  Fly   326 WAVTN-IDYIHSRTSNRVFMMIFCVWTAAVIVSLAP-QFGWKDPDYLQRI----EQQKCMVSQDV 384

Human   198 AYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQK------------------------------ 232
            :|.:.::..:|||||::::.:|.:::|.|::::.:                              
  Fly   385 SYQVFATCCTFYVPLLVILALYWKIYQTARKRIHRRRPRPVDAAVNNNQPDGGAATDTKLHRLRL 449

Human   233 ----------------------------------------------------------------- 232
                                                                             
  Fly   450 RLGRFSTAKSKTGSAVGVSGPASGGRALGLVDGNSTNTVNTVEDTEFSSSNVDSKSRAGVEAPST 514

Human   233 -------------IDKSEGRFHVQNLSQV---------EQDG-RTGHG----------------- 257
                         :.|.:|:...::.:.|         |.|| |..||                 
  Fly   515 SGNQIATVSHLVALAKQQGKSTAKSSAAVNGMAPSGRQEDDGQRPEHGEQEDREELEDQDEQVGP 579

Human   258 -------------------------------------------LRRSSK---------------- 263
                                                       |::|.|                
  Fly   580 QPTTATSAMTAAGTNESEDQCKANGVEVLEDPQLQQQLEQVQQLQKSVKSGGGGGASTSNATTIT 644

Human   264 ----------------------------------------FC----------------------- 265
                                                    .|                       
  Fly   645 SISALSPQTPTSQGVGIAAAAAGPMTAKTSTLTSCNQSHPLCGTANESPSTPEPRSRQPTTPQQQ 709

Human   266 ----------------------------------LKEHKALKTLGIIMGTFTLCWLPFFIVNI-V 295
                                              .:|.||.|||.||.|.|.:||||||::.: :
  Fly   710 PHQQAHQQQQQQQQLSSIANPMQKVNKRKETLEAKRERKAAKTLAIITGAFVVCWLPFFVMALTM 774

Human   296 HVIQDNLIRKEVYILLNWIGYVNSGFNPLIY-CRSPDFRIAFQELL 340
            .:.....|...|..|..|:||.||..||:|| ..||:||.||:.:|
  Fly   775 PLCAACQISDSVASLFLWLGYFNSTLNPVIYTIFSPEFRQAFKRIL 820

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ADRB2NP_000015.2 7tmA_Beta2_AR 34..336 CDD:341355 114/597 (19%)
TM helix 1 35..61 CDD:341355 10/28 (36%)
TM helix 2 68..95 CDD:341355 12/26 (46%)
TM helix 3 106..136 CDD:341355 20/29 (69%)
TM helix 4 148..171 CDD:341355 6/22 (27%)
TM helix 5 196..228 CDD:341355 9/31 (29%)
TM helix 6 266..296 CDD:341355 16/30 (53%)
TM helix 7 305..330 CDD:341355 11/25 (44%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 392..413
PDZ-binding 410..413
5-HT1ANP_001356890.1 7tmA_5-HT1A_invertebrates 227..>413 CDD:320454 67/191 (35%)
TM helix 1 228..254 CDD:320454 9/25 (36%)
TM helix 2 261..287 CDD:320454 12/25 (48%)
TM helix 3 299..329 CDD:320454 20/29 (69%)
TM helix 4 340..362 CDD:320454 6/22 (27%)
TM helix 5 383..412 CDD:320454 7/28 (25%)
7tm_GPCRs <743..816 CDD:475119 32/72 (44%)
TM helix 6 750..772 CDD:410628 13/21 (62%)
TM helix 7 784..809 CDD:410628 11/24 (46%)
Blue background indicates that the domain is not in the aligned region.

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