Protein Alignment ADRB2 and mAChR-C

DIOPT Version :10

• Sequence 1: NP_000015.2
• Gene: ADRB2 / 154
• HGNCID: 286
• Length: 413
• Species: Homo sapiens
• Sequence 2: NP_572358.1
• Gene: mAChR-C / 31626
• FlyBaseID: FBgn0029909
• Length: 371
• Species: Drosophila melanogaster
• Alignment Length: 327
• Identity: 96/327 - (29%)
• Similarity: 152/327 - (46%)
• Gaps: 52/327 - (15%)

Human    35 GMGIVMSLIVLAIVF-----GNVLVITAIAKFERLQTV-TNYFITSLACADLVMGLAVVPFGAAH 93
            |.|.::.|.:.|.:|     ||:|.|.|:.....|::| :|.||.|||.:|..:||| :|:   |
  Fly    47 GAGHLLWLAINAFLFVLILGGNILTIVAVRTCRHLRSVISNLFILSLAVSDFCVGLA-LPY---H 107

Human    94 ILMKMWT-----FGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVI 153
            ::..|.:     .|.....|:..|...||  |:.||..||||||.|:.....|:..:|:..|..|
  Fly   108 LVFYMGSDIGAMRGPCLLRFFLLICACCV--SMLTLISIAVDRYIAVVYALHYRRYMTRRVAYSI 170

Human   154 ILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVS--FYVPLVIMV 216
            |:..|.:..|.:.||:  .|         |.:.:...|:|....|....:.:::  |.:..:.|.
  Fly   171 IIFNWCLGALVALLPV--FW---------NRWPDAQACEFDEVLAPGYIAGVITPGFVIIWICMF 224

Human   217 FVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGT 281
            .||.|:.:||.:|..::.:|.    |.|         |.......:.....:.|:::.:..|||.
  Fly   225 LVYWRIMREASKQALRLRQSV----VYN---------TDEATTMRNLLLHPDWKSVQIVVFIMGC 276

Human   282 FTLCWLPFFIVNIVHVI----QDNLIRKEVYILLNWIGYVNSGFNPLIYC-RSPDFRIAFQELLC 341
            |||||||:|.|.|..:.    ..::|.|..:.|    ...||..||:||. ::..||.||.:.||
  Fly   277 FTLCWLPYFCVAIAQLFSICQSSSMIYKTTFSL----AIANSALNPIIYSWKNSGFRRAFVQTLC 337

Human   342 LR 343
            .|
  Fly   338 CR 339

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ADRB2	NP_000015.2	7tmA_Beta2_AR	34..336	CDD:341355	91/318 (29%)
		TM helix 1	35..61	CDD:341355	10/30 (33%)
		TM helix 2	68..95	CDD:341355	12/26 (46%)
		TM helix 3	106..136	CDD:341355	14/29 (48%)
		TM helix 4	148..171	CDD:341355	7/22 (32%)
		TM helix 5	196..228	CDD:341355	8/33 (24%)
		TM helix 6	266..296	CDD:341355	14/29 (48%)
		TM helix 7	305..330	CDD:341355	8/25 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	392..413
		PDZ-binding	410..413
mAChR-C	NP_572358.1	7tm_classA_rhodopsin-like	53..325	CDD:410626	87/305 (29%)
		TM helix 1	53..78	CDD:410626	8/24 (33%)
		TM helix 2	86..111	CDD:410626	12/28 (43%)
		TM helix 3	123..153	CDD:410626	14/31 (45%)
		TM helix 4	166..185	CDD:410626	5/18 (28%)
		TM helix 5	204..229	CDD:410626	5/24 (21%)
		TM helix 6	261..291	CDD:410626	14/29 (48%)
		TM helix 7	300..325	CDD:410626	9/28 (32%)