DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ADRB2 and adrb2

DIOPT Version :9

Sequence 1:	NP_000015.2	Gene:	ADRB2 / 154	HGNCID:	286	Length:	413	Species:	Homo sapiens
Sequence 2:	NP_001116897.2	Gene:	adrb2 / 100144654	XenbaseID:	XB-GENE-494302	Length:	419	Species:	Xenopus tropicalis

Alignment Length:	420	Identity:	266/420 - (63%)
Similarity:	317/420 - (75%)	Gaps:	45/420 - (10%)

- Green bases have known domain annotations that are detailed below.

Human    15 NGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACAD 79
            |.|:|.|     :..:.|:|||||:||.|||.||.||||||||||||:|||||||||||||||||
Frog    24 NTSNASD-----KPGDAWMVGMGIIMSCIVLVIVLGNVLVITAIAKFQRLQTVTNYFITSLACAD 83

Human    80 LVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSL 144
            |:|||.||||||:.|::..|.|.|||||||||:|:|||||||||||||||||||||||||:||||
Frog    84 LLMGLIVVPFGASSIILDTWVFNNFWCEFWTSVDILCVTASIETLCVIAVDRYFAITSPFRYQSL 148

Human   145 LTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFY 209
            |||.|||::||:||:||.|||||||.|||||...:.|::||.:.:||.||||.||||:|||:|||
Frog   149 LTKCKARIVILLVWVVSTLTSFLPIYMHWYRIEEESALHCYDDPSCCFFFTNPAYAISSSIISFY 213

Human   210 VPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKT 274
            :|||:|:|||:|||||||:||:||||||||||.|| :|.:.:|:.|:  :|:|||.|||||||||
Frog   214 LPLVVMIFVYARVFQEAKKQLKKIDKSEGRFHNQN-NQQDTNGKQGN--KRTSKFWLKEHKALKT 275

Human   275 LGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQEL 339
            |||||||||||||||||||||.|:..:.|..:||..|||:|||||.|||||||||||||..||||
Frog   276 LGIIMGTFTLCWLPFFIVNIVQVMHKDFIPVKVYNFLNWVGYVNSAFNPLIYCRSPDFRYTFQEL 340

Human   340 LCLRRSSLKAYGNGY-SSNGNTGEQSGYHVEQE--------------KENK------LLCEDLPG 383
            ||||:...|||.||| .||||    |.|:.:.|              ||.|      |.||
Frog   341 LCLRKPGSKAYANGYPQSNGN----SAYNEDTEPCQYSKDRTCEVLFKEEKTPNPSLLNCE---- 397

Human   384 TEDFVGHQGTVPSDNIDSQGRNCSTNDSLL 413
                    ||:...:::..|:|.:|:|.||
Frog   398 --------GTLLDFSLEPLGKNHNTHDCLL 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ADRB2	NP_000015.2	7tmA_Beta2_AR	34..336	CDD:341355	226/301 (75%)
		TM helix 1	36..60	CDD:341355	19/23 (83%)
		TM helix 2	69..91	CDD:341355	19/21 (90%)
		TM helix 3	107..129	CDD:341355	19/21 (90%)
		TM helix 4	152..168	CDD:341355	10/15 (67%)
		TM helix 5	197..220	CDD:341355	16/22 (73%)
		TM helix 6	272..294	CDD:341355	21/21 (100%)
		TM helix 7	305..330	CDD:341355	18/24 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	392..413		6/20 (30%)
		PDZ-binding	410..413		1/2 (50%)
adrb2	NP_001116897.2	7tmA_Beta2_AR	38..337	CDD:341355	226/301 (75%)
		TM helix 1	39..65	CDD:341355	21/25 (84%)
		TM helix 2	72..99	CDD:341355	22/26 (85%)
		TM helix 3	110..140	CDD:341355	27/29 (93%)
		TM helix 4	152..175	CDD:341355	16/22 (73%)
		TM helix 5	200..232	CDD:341355	24/31 (77%)
		TM helix 6	267..297	CDD:341355	29/29 (100%)
		TM helix 7	306..331	CDD:341355	18/24 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	434	1.000	Domainoid score	I5097
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H30948
Inparanoid	1	1.050	519	1.000	Inparanoid score	I7450
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG48050
OrthoDB	1	1.010	-	-		D165225at32523
OrthoFinder	1	1.000	-	-		FOG0002077
OrthoInspector	1	1.000	-	-		oto151990
Panther	1	1.100	-	-	LDO	PTHR24248
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X822
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.080