DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hnrnpab and sqd

DIOPT Version :9

Sequence 1:	NP_001041526.1	Gene:	Hnrnpab / 15384	MGIID:	1330294	Length:	332	Species:	Mus musculus
Sequence 2:	NP_731825.1	Gene:	sqd / 41666	FlyBaseID:	FBgn0263396	Length:	344	Species:	Drosophila melanogaster

Alignment Length:	369	Identity:	132/369 - (35%)
Similarity:	185/369 - (50%)	Gaps:	67/369 - (18%)

- Green bases have known domain annotations that are detailed below.

Mouse     5 AEEQPMETTGATENGHEAAPEGEAPVEPSAAAAAPAASAGSGGGTTTAPSGNQNGAEGDQINASK 69
            ||.:.::|   ..||.:...:        ..|..|.:..|..|.     :|:.||:..:|..||.
  Fly     2 AENKQVDT---EINGEDFTKD--------VTADGPGSENGDAGA-----AGSTNGSSDNQSAASG 50

Mouse    70 NEEDAGKMFVGGLSWDTSKKDLKDYFTKFGEVVDCTIKMDPNTGRSRGFGFILFKDSSSVEKVLD 134
            ..:|..|:|||||||:|::|:|:|:|.|:||:....:|.||.|||||||.||:|.::.:::||..
  Fly    51 QRDDDRKLFVGGLSWETTEKELRDHFGKYGEIESINVKTDPQTGRSRGFAFIVFTNTEAIDKVSA 115

Mouse   135 QKEHRLDGRVIDPKKAMAMKKDPVKKIFVGGLNPEATEEKIREYFGQFGEIEAIELPIDPKLNKR 199
            ..||.::.:.:|||||.|..    .|||||||..|.::|:|:.||||||.|..:|:|.|.:.::|
  Fly   116 ADEHIINSKKVDPKKAKARH----GKIFVGGLTTEISDEEIKTYFGQFGNIVEVEMPFDKQKSQR 176

Mouse   200 RGFVFITFKEEDPVKKVLEKKFHTVSGSKCEIKVAQPKEVYQQQQYGSGGRGNRNRGNRGSGGGQ 264
            :||.||||..|..|..:|:.....::|.:.::|.|.||...|......||.....||.||..||:
  Fly   177 KGFCFITFDSEQVVTDLLKTPKQKIAGKEVDVKRATPKPENQMMGGMRGGPRGGMRGGRGGYGGR 241

Mouse   265 SQSWNQGYGNYWNQGYGYQQGYGPGYGGYDYSPYG-YY--GYGPGYDYSQ--------------- 311
            .     ||.|.|: |.|...|||.|||||....|| ||  ||..||||..
  Fly   242 G-----GYNNQWD-GQGSYGGYGGGYGGYGAGGYGDYYAGGYYNGYDYGYDGYGYGGGFEGNGYG 300

Mouse   312 -----------------------GSTNYGKSQRRGGHQNNYKPY 332
                                   |..|.||.:..||.|..::||
  Fly   301 GGGGGNMGGGRGGPRGGGGPKGGGGFNGGKQRGGGGRQQRHQPY 344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hnrnpab	NP_001041526.1	CBFNT	1..75	CDD:285369	16/69 (23%)
		RRM1_hnRNPAB	76..150	CDD:241201	36/73 (49%)
		RRM2_hnRNPAB	155..234	CDD:241028	32/78 (41%)
sqd	NP_731825.1	RRM_SF	58..129	CDD:302621	33/70 (47%)
sqd	NP_731825.1	RRM2_hnRNPD_like	137..211	CDD:240775	32/73 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	85	1.000	Domainoid score	I8163
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	226	1.000	Inparanoid score	I3473
Isobase	1	0.950	-	0.918296	Normalized mean entropy	S1109
OMA	1	1.010	-	-		QHG45859
OrthoDB	1	1.010	-	-		D496221at33208
OrthoFinder	1	1.000	-	-		FOG0001417
OrthoInspector	1	1.000	-	-		otm43940
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR48033
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4769
SonicParanoid	1	1.000	-	-		X985
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	13.020