Protein Alignment RNF145 and HRD1

DIOPT Version :9

• Sequence 1: NP_001186309.1
• Gene: RNF145 / 153830
• HGNCID: 20853
• Length: 693
• Species: Homo sapiens
• Sequence 2: NP_014630.1
• Gene: HRD1 / 854149
• SGDID: S000005373
• Length: 551
• Species: Saccharomyces cerevisiae
• Alignment Length: 574
• Identity: 114/574 - (19%)
• Similarity: 195/574 - (33%)
• Gaps: 147/574 - (25%)

Human   212 EVLYFLGSNLLVPYNLAKSAYRELVQVVEVYGLLALGMSLWNQLVVPVLFM----VFWLVLFALQ 272
            ::..|:....|:.:....||.:..|..::|...|..|   :|.:|:.:..:    :.|.:|..|
Yeast     9 QLAIFVVVTYLLTFYCVYSATKTSVSFLQVTLKLNEG---FNLMVLSIFILLNSTLLWQLLTKL- 69

Human   273 IYSYFSTRDQPASRERLLF-----LFLTSIAECCSTPYSLLGLVFTVSFVALGVLTLCKFYLQGY 332
            ::......:.....|||.|     ||::|:..   ..|     .|||:|  .|:|.|   ||:.:
Yeast    70 LFGELRLIEHEHIFERLPFTIINTLFMSSLFH---ERY-----FFTVAF--FGLLLL---YLKVF 121

Human   333 RAFMND--PAMNRGMTEGVTLLILAVQTGLIELQVVHRAFLLSIILFIVVASILQSMLEIADPIV 395
            ...:.|  .|:.:.:.:..|:..|........|      .||:::.:.::...:.|:.
Yeast   122 HWILKDRLEALLQSINDSTTMKTLIFSRFSFNL------VLLAVVDYQIITRCISSIY------- 173

Human   396 LALGASRDKSLWKHFRAVSLCLF-LLVFPAYMAYMICQFFH--MDFWLLIIISSSILTSLQVLGT 457
                 :..||   ...:.||.|. ::.|...:..::..|..  ::||       ....|.|.|..
Yeast   174 -----TNQKS---DIESTSLYLIQVMEFTMLLIDLLNLFLQTCLNFW-------EFYRSQQSLSN 223

Human   458 LFIYVLF-------MVEEFRKEPVENMDDVIYYVNGTYRLLE--FLVALCVVAYGVSETIFGEWT 513
            ...:::.       .||..:.:||.|.||.....:..:..||  |:....:..:    |.|.:..
Yeast   224 ENNHIVHGDPTDENTVESDQSQPVLNDDDDDDDDDRQFTGLEGKFMYEKAIDVF----TRFLKTA 284

Human   514 VMGSMIIFIHS--------YYNVWLRAQLGWKSFLLRRDAVNKIKSLPIATKEQLEKH-ND--IC 567
            :..||:|....        .:::....|.|...:.:.|:......:|...|.|||:.. ||  ||
Yeast   285 LHLSMLIPFRMPMMLLKDVVWDILALYQSGTSLWKIWRNNKQLDDTLVTVTVEQLQNSANDDNIC 349

Human   568 AICYQDM-------------KSAVITPCSHFFHAGCLKKWLYVQETCPLCHCHL----------- 608
            .||..::             |.....||.|..|..|||.|:...:|||:|...:
Yeast   350 IICMDELIHSPNQQTWKNKNKKPKRLPCGHILHLSCLKNWMERSQTCPICRLPVFDEKGNVVQTT 414

Human   609 --KNS-------------------------SQLPGLGTEPVLQ--PHAGAEQNVMFQEGTEPPGQ 644
              .||                         ..||...|.|.::  |....:...|....|..|..
Yeast   415 FTSNSDITTQTTVTDSTGIATDQQGFANEVDLLPTRTTSPDIRIVPTQNIDTLAMRTRSTSTPSP 479

Human   645 E------HTPGTRIQEGSRDNNEYIARRPDNQEGAFDPKEYPHSAKDEAHPVES 692
            .      |..|......||...|::....|.:|...     |.....|.|.|.|
Yeast   480 TWYTFPLHKTGDNSVGSSRSAYEFLITNSDEKENGI-----PVKLTIENHEVNS 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RNF145	NP_001186309.1	TRC8_N	38..536	CDD:290425	66/354 (19%)
		zf-rbx1	<564..605	CDD:289448	18/55 (33%)
		zf-RING_2	565..605	CDD:290367	17/54 (31%)
HRD1	NP_014630.1	HRD1	5..551	CDD:227568	114/574 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C159050017
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5243
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740