Protein Alignment RNF145 and rnf145a

DIOPT Version :9

• Sequence 1: NP_001186309.1
• Gene: RNF145 / 153830
• HGNCID: 20853
• Length: 693
• Species: Homo sapiens
• Sequence 2: XP_005157379.1
• Gene: rnf145a / 565986
• ZFINID: ZDB-GENE-111012-3
• Length: 649
• Species: Danio rerio
• Alignment Length: 640
• Identity: 534/640 - (83%)
• Similarity: 581/640 - (90%)
• Gaps: 8/640 - (1%)

Human    31 MAAKEKLEAVLNVALRVPSIMLLDVLYRWDVSSFFQQIQRSSLSNNPLFQYKYLALNMHYVGYIL 95
            ||.||::||||||.|||||||||:||||||||||||:||||||:||||||||||||.:|||||||
Zfish     1 MAVKERVEAVLNVGLRVPSIMLLEVLYRWDVSSFFQKIQRSSLNNNPLFQYKYLALYLHYVGYIL 65

Human    96 SVVLLTLPRQHLVQLYLYFLTALLLYAGHQISRDYVRSELEFAYEGPMYLEPLSMNRFTTALIGQ 160
            |:||||||||||||||||.||||||:|||||||||||||||..||||:||||||:|||||||:.|
Zfish    66 SLVLLTLPRQHLVQLYLYVLTALLLFAGHQISRDYVRSELESGYEGPLYLEPLSINRFTTALLCQ 130

Human   161 LVVCTLCSCVMKTKQIWLFSAHMLPLLARLCLVPLETIVIINKFAMIFTGLEVLYFLGSNLLVPY 225
            |||||||||||:||:|||||||:|||:||||||||||||.:|:||||||||||:|||.||||||:
Zfish   131 LVVCTLCSCVMQTKRIWLFSAHLLPLVARLCLVPLETIVFVNRFAMIFTGLEVIYFLASNLLVPF 195

Human   226 NLAKSAYRELVQVVEVYGLLALGMSLWNQLVVPVLFMVFWLVLFALQIYSYFSTRDQPASRERLL 290
            ||||:|||||.||||||||||||||||||||:|||||.|||||||||||:||||||||.||||||
Zfish   196 NLAKTAYRELAQVVEVYGLLALGMSLWNQLVLPVLFMCFWLVLFALQIYTYFSTRDQPTSRERLL 260

Human   291 FLFLTSIAECCSTPYSLLGLVFTVSFVALGVLTLCKFYLQGYRAFMNDPAMNRGMTEGVTLLILA 355
            |||||||||||.||||||||||||||||||||||||||||||||||||..|:||||||:||||||
Zfish   261 FLFLTSIAECCCTPYSLLGLVFTVSFVALGVLTLCKFYLQGYRAFMNDNTMHRGMTEGITLLILA 325

Human   356 VQTGLIELQVVHRAFLLSIILFIVVASILQSMLEIADPIVLALGASRDKSLWKHFRAVSLCLFLL 420
            ||||||||||:||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   326 VQTGLIELQVIHRAFLLSIILFIVVASILQSMLEIADPIVLALGASRDKSLWKHFRAVSLCLFLL 390

Human   421 VFPAYMAYMICQFFHMDFWLLIIISSSILTSLQVLGTLFIYVLFMVEEFRKEPVENMDDVIYYVN 485
            ||||||:|||||||||||||||||||||||||||||||.|||||||||.||.||||||||||:||
Zfish   391 VFPAYMSYMICQFFHMDFWLLIIISSSILTSLQVLGTLLIYVLFMVEELRKAPVENMDDVIYWVN 455

Human   486 GTYRLLEFLVALCVVAYGVSETIFGEWTVMGSMIIFIHSYYNVWLRAQLGWKSFLLRRDAVNKIK 550
            ||||||||||||||||||||||:|||||||||.|:.|||||||||||||||:|||||||||||||
Zfish   456 GTYRLLEFLVALCVVAYGVSETVFGEWTVMGSTIVLIHSYYNVWLRAQLGWQSFLLRRDAVNKIK 520

Human   551 SLPIATKEQLEKHNDICAICYQDMKSAVITPCSHFFHAGCLKKWLYVQETCPLCHCHLKNSSQLP 615
            |||.|:.:||::|||||:||||||.|||||||||.||||||||||||||||||||..||.||||
Zfish   521 SLPTASLQQLQQHNDICSICYQDMTSAVITPCSHLFHAGCLKKWLYVQETCPLCHNQLKGSSQL- 584

Human   616 GLGTEPVLQPHAGAEQNVMFQEGTEPPGQEHTPGTRIQEGSRDNNEYIARRPDNQ 670
            |..::.| .|.....|....|:.:||...|    :.:|:..:|::.  .|.|.::
Zfish   585 GSSSQDV-PPQDTPAQPEEDQDPSEPADSE----SNLQDLRQDDSS--TRAPASE 632

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RNF145	NP_001186309.1	TRC8_N	38..536	CDD:290425	451/497 (91%)
		zf-rbx1	<564..605	CDD:289448	37/40 (93%)
		zf-RING_2	565..605	CDD:290367	36/39 (92%)
rnf145a	XP_005157379.1	TRC8_N	8..506	CDD:290425	451/497 (91%)
		zf-RING_2	535..575	CDD:290367	36/39 (92%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194341076
Domainoid	1	1.000	912	1.000	Domainoid score	I563
eggNOG	1	0.900	-	-		E1_COG5243
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1059	1.000	Inparanoid score	I2054
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG46488
OrthoDB	1	1.010	-	-		D119734at7742
OrthoFinder	1	1.000	-	-		FOG0006288
OrthoInspector	1	1.000	-	-		otm27927
orthoMCL	1	0.900	-	-		OOG6_109881
Panther	1	1.100	-	-	LDO	PTHR22763
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7680
SonicParanoid	1	1.000	-	-		X4575
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	17	17.300