Protein Alignment RNF145 and hrd1

DIOPT Version :9

• Sequence 1: NP_001186309.1
• Gene: RNF145 / 153830
• HGNCID: 20853
• Length: 693
• Species: Homo sapiens
• Sequence 2: NP_596376.1
• Gene: hrd1 / 2539900
• PomBaseID: SPBC17D11.02c
• Length: 677
• Species: Schizosaccharomyces pombe
• Alignment Length: 511
• Identity: 101/511 - (19%)
• Similarity: 187/511 - (36%)
• Gaps: 173/511 - (33%)

Human   259 VLFMVFWLVLFALQIYSYFSTRDQPASRERLLFLFLTSIAECCSTPYSLLGLVF-TVSFVALGV- 321
            :|:::..||||.|.:               ||.|:.:      :..||...::. :...:.:|:
pombe     4 ILYVLASLVLFGLSV---------------LLSLYSS------ANVYSATVMISQSPVHITIGLN 47

Human   322 LTLCKFYLQGYRAFMNDPAMNRGMTEGVTLLILAVQTGLIELQVVHRAFLLSIILFIVVASILQS 386
            :.||.|:     |..|  |:.       |||..::||  .||::::..|.:::
pombe    48 VCLCLFF-----AIAN--ALK-------TLLFGSLQT--FELELLYEQFWITL------------ 84

Human   387 MLEIADPIVLALGASRDKSLWKHFRAVSLCLFLLVFPAYMAYMICQF-------------FHM-- 436
                 ..|:||:...|:......|..:|..:|..||     :.||.|             ||:
pombe    85 -----TEIMLAITVFREAISISFFMLLSTLMFARVF-----HSICSFRTERLQIQLTDQRFHIFS 139

Human   437 ----DFWLLIIISSSILTSLQVLGTLFIYVLFMVEEFRKEPVENMDDVIYYVNGTYRLLEFLV-- 495
                .:::|.|:.:|:           ||:.|..|....:...    :::....:..||...:
pombe   140 RLTCAYFVLSILDASL-----------IYLCFTSEHLGDKSTR----MLFVCEFSVLLLNLTIEA 189

Human   496 -ALCVVAYGVS--ETIFGEWT--------------VMGSMIIFIHS-----------------YY 526
             .||:..|...  :.::.|.:              ::...::|::.                 :|
pombe   190 SKLCIYLYEARHLDQVWDEKSTYLFRLEVCRDGLRLLAYSLLFMYQFPYVSVPIYSIRQMYTCFY 254

Human   527 NVWLRAQLGWKSFLLRRDAVNKIKSL-PIATKEQLEKHNDICAICYQDM---------------- 574
            :::.|.    :.....|.|...:.:: |.||:|||...:..|.||.::|
pombe   255 SLFRRI----REHARFRQATRDMNAMYPTATEEQLTNSDRTCTICREEMFHPDHPPENTDEMEPL 315

Human   575 -KSAVIT----PCSHFFHAGCLKKWLYVQETCPLC-HCHLKNSSQLPGLGTEPVLQPHAGAEQNV 633
             :...:|    ||.|..|..||:.||..|:|||:| ...:.|.|...|:...|          ||
pombe   316 PRGLDMTPKRLPCGHILHFHCLRNWLERQQTCPICRRSVIGNQSSPTGIPASP----------NV 370

Human   634 -MFQEGTEPPGQEHTPGTRIQEGSRDNNEYIARRPDNQEGAFDPKEYPHSAKDEAH 688
             ..|..|:.|..::||.|....|..::    :.:.|.|...|:.....:|:...||
pombe   371 RATQIATQVPNPQNTPTTTAVPGITNS----SNQGDPQASTFNGVPNANSSGFAAH 422

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RNF145	NP_001186309.1	TRC8_N	38..536	CDD:290425	56/333 (17%)
		zf-rbx1	<564..605	CDD:289448	18/62 (29%)
		zf-RING_2	565..605	CDD:290367	18/61 (30%)
hrd1	NP_596376.1	HRD1	1..514	CDD:227568	101/511 (20%)
		zf-RING_2	291..351	CDD:290367	17/59 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5243
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.770