DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RNF145 and rnf-145

DIOPT Version :9

Sequence 1:	NP_001186309.1	Gene:	RNF145 / 153830	HGNCID:	20853	Length:	693	Species:	Homo sapiens
Sequence 2:	NP_491382.2	Gene:	rnf-145 / 172053	WormBaseID:	WBGene00022471	Length:	742	Species:	Caenorhabditis elegans

Alignment Length:	676	Identity:	198/676 - (29%)
Similarity:	340/676 - (50%)	Gaps:	64/676 - (9%)

- Green bases have known domain annotations that are detailed below.

Human    34 KEKLEAVLNVALRVPSIMLLDVLYRWDVSSFFQQIQRSSLSNNPLFQY---------------KY 83
            ||....||...||:|.::.:::|:|:...| |:.|....:...||..:               .:
Worm    45 KEMSIMVLETGLRLPGLLFIELLWRYQGFS-FEDISDDMMKQTPLSYFDIPTMLDFVHRRNFDHH 108

Human    84 LALNMHYVGYILSVVLLTLPRQHLVQLYLYFLTALLLYAGHQISRDYVRSEL-----EFAYEGPM 143
            .|:.:.|....:|::.||||...|:::|.:||:..|....:::|..||..|:     |...:|.:
Worm   109 AAIILSYFVIFISLMFLTLPLSRLIRMYSHFLSVFLFGVAYKLSAIYVDLEMKTGEEELKLDGLI 173

Human   144 YLEPLSMNRFTTALIGQLVVCTLCSCVMKTK-QIW--LFSAHMLPLLARLCLVPLETIVIINKFA 205
            .||     |.....:.|:::..|.|.:::.. :.|  ......||::||:|..|::.:...:.:|
Worm   174 KLE-----RHGFHFLAQMLLVVLQSMLLEVDGEPWRVALPVFALPIVARMCGCPMDKLKNAHNYA 233

Human   206 ----MIFTGLEVLYFLGSNLLVPYNLAKSAYRELVQVVEVYGLLALGMS-LWNQLVVPVLFMVFW 265
                |||....:||...|.:    ...|:|.|::..|..|:| ||.|:: ||.:|.:..|....|
Worm   234 CTGTMIFIATYMLYRAPSLI----KSTKTALRQIKAVFMVHG-LADGVAVLWRKLRILELLTFTW 293

Human   266 LVLFALQIYSYFSTRDQPASR-ERLLFLFLTSIAECCSTPYSLLGLVFTVSFVALGVLTLCKFYL 329
            :.:|.:.:|.....:.:..|. .|:|   ||.:||..:||.:|..|..:||:|...:..|.|...
Worm   294 ITMFLMVLYVELIDKGRTWSEVGRIL---LTGVAETTNTPITLAALAVSVSYVCKWIADLTKLIT 355

Human   330 QGYRAFMNDPAMNRGMTEGVTLLILAVQTGLIELQVVHRAFLLSIILFIVVASILQSMLEIADPI 394
            .|.|:..:..| :.|.||.|:::||.:|||.:.:||..:..||:::|:||::::|||:.||.:.:
Worm   356 GGTRSHGHVLA-HSGYTEAVSVVILCIQTGFLGMQVEQKTILLALVLYIVISALLQSLFEIIEVV 419

Human   395 VLALGASRDKSLWKHFRAVSLCLFLLVFPAYMAYMICQFFHMDFWLLIIISSSILTSLQVLGTLF 459
            :|.|.:|...|..:|.|.:.:.|.|:|.|.:....:.....:|.:..|||::|...:.:.:|.:.
Worm   420 LLNLPSSPTASRARHARCICIALLLVVIPFFTTKTMLALLPIDIYTAIIIANSATVTARAIGVIL 484

Human   460 IYVLFMVEEFRKEPVENMDDVIYYVNGTYRLLEFLVALCVVAYGVSETIFGEWTVMGSMIIFIHS 524
            .|::.:||...:||.|.:||:.||::...:.:|.|.|..|:.:|..:.:...::.....|:..|.
Worm   485 KYIVLIVETKSEEPWEGIDDLTYYIDCANKGIELLAAKVVMVFGCMQVVKVGFSFATFAILLFHV 549

Human   525 YYNVWLRAQLGWKSFLLRRD-AVNKIKSLPIATKEQLEKHNDICAICYQDMK-SAVITPCSHFFH 587
            ..|::.|.: ...||:..|: ||..|..|..|...||.:..|:||||:.:|| .|.||||.|:||
Worm   550 IVNIYKRLE-HTVSFIKNRNAAVKNINRLSKADVVQLREREDVCAICFIEMKEEARITPCKHYFH 613

Human   588 AGCLKKWLYVQETCPLCHCHLKN---SSQLPGLGT-EPVLQPHAGA--EQNVMF-QEGTEPPGQE 645
            ..||:|||.|:..||||:.::|.   .|:....|| ..|.|...||  |:|... :|..|.|..|
Worm   614 GPCLRKWLAVKMVCPLCYTYMKEDDFDSKSSSSGTLNEVQQNEEGAAVEENPENPEEQPEAPNAE 678

Human   646 HTPGT----------RIQEGSRDNNE 661
            ..||.          |.:..:|:.||
Worm   679 RAPGDMFDWDDLFGFRAERETRNRNE 704

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RNF145	NP_001186309.1	TRC8_N	38..536	CDD:290425	141/526 (27%)
		zf-rbx1	<564..605	CDD:289448	24/41 (59%)
		zf-RING_2	565..605	CDD:290367	24/40 (60%)
rnf-145	NP_491382.2	TRC8_N	49..556	CDD:372682	140/521 (27%)
rnf-145	NP_491382.2	RING-H2_RNF139_like	590..631	CDD:319390	24/40 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	198	1.000	Domainoid score	I2005
eggNOG	1	0.900	-	-		E1_COG5243
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	269	1.000	Inparanoid score	I2110
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46488
OrthoDB	1	1.010	-	-		D302551at33208
OrthoFinder	1	1.000	-	-		FOG0006288
OrthoInspector	1	1.000	-	-		oto20943
orthoMCL	1	0.900	-	-		OOG6_109881
Panther	1	1.100	-	-	O	PTHR22763
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7680
SonicParanoid	1	1.000	-	-		X4575
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.870